Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:141479000" > Non-coding variabil...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 12077naa a2204057 4500 | |
001 | oai:prod.swepub.kib.ki.se:141479000 | |
003 | SwePub | |
008 | 240701s2019 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1414790002 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-10945-z2 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zhou, XP4 aut |
245 | 1 0 | a Non-coding variability at the APOE locus contributes to the Alzheimer's risk |
264 | c 2019-07-25 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. These risk haplotypes are associated with changes of AD-related endophenotypes including cognitive performance, and altered expression of APOE and its nearby genes in the human brain and blood. High-throughput genome-wide chromosome conformation capture analysis further supports the roles of these risk haplotypes in modulating chromatin states and gene expression in the brain. Our findings provide compelling evidence for additional risk factors in the APOE locus that contribute to AD pathogenesis. | |
700 | 1 | a Chen, Y4 aut |
700 | 1 | a Mok, KY4 aut |
700 | 1 | a Kwok, TCY4 aut |
700 | 1 | a Mok, VCT4 aut |
700 | 1 | a Guo, QH4 aut |
700 | 1 | a Ip, FC4 aut |
700 | 1 | a Chen, YW4 aut |
700 | 1 | a Mullapudi, N4 aut |
700 | 1 | a Giusti-Rodriguez, P4 aut |
700 | 1 | a Sullivan, PF4 aut |
700 | 1 | a Hardy, J4 aut |
700 | 1 | a Fu, AKY4 aut |
700 | 1 | a Li, Y4 aut |
700 | 1 | a Ip, NY4 aut |
700 | 1 | a Weiner, MW4 aut |
700 | 1 | a Aisen, P4 aut |
700 | 1 | a Petersen, R4 aut |
700 | 1 | a Jack, CR4 aut |
700 | 1 | a Jagust, W4 aut |
700 | 1 | a Trojanowski, JQ4 aut |
700 | 1 | a Toga, AW4 aut |
700 | 1 | a Beckett, L4 aut |
700 | 1 | a Green, RC4 aut |
700 | 1 | a Saykin, AJ4 aut |
700 | 1 | a Morris, J4 aut |
700 | 1 | a Shaw, LM4 aut |
700 | 1 | a Khachaturian, Z4 aut |
700 | 1 | a Sorensen, G4 aut |
700 | 1 | a Kuller, L4 aut |
700 | 1 | a Raichle, M4 aut |
700 | 1 | a Paul, S4 aut |
700 | 1 | a Davies, P4 aut |
700 | 1 | a Fillit, H4 aut |
700 | 1 | a Hefti, F4 aut |
700 | 1 | a Holtzman, D4 aut |
700 | 1 | a Mesulam, MM4 aut |
700 | 1 | a Potter, W4 aut |
700 | 1 | a Snyder, P4 aut |
700 | 1 | a Schwartz, A4 aut |
700 | 1 | a Montine, T4 aut |
700 | 1 | a Thomas, RG4 aut |
700 | 1 | a Donohue, M4 aut |
700 | 1 | a Walter, S4 aut |
700 | 1 | a Gessert, D4 aut |
700 | 1 | a Sather, T4 aut |
700 | 1 | a Jiminez, G4 aut |
700 | 1 | a Harvey, D4 aut |
700 | 1 | a Bernstein, M4 aut |
700 | 1 | a Thompson, P4 aut |
700 | 1 | a Schuff, N4 aut |
700 | 1 | a Borowski, B4 aut |
700 | 1 | a Gunter, J4 aut |
700 | 1 | a Senjem, M4 aut |
700 | 1 | a Vemuri, P4 aut |
700 | 1 | a Jones, D4 aut |
700 | 1 | a Kantarci, K4 aut |
700 | 1 | a Ward, C4 aut |
700 | 1 | a Koeppe, RA4 aut |
700 | 1 | a Foster, N4 aut |
700 | 1 | a Reiman, EM4 aut |
700 | 1 | a Chen, KW4 aut |
700 | 1 | a Mathis, C4 aut |
700 | 1 | a Landau, S4 aut |
700 | 1 | a Cairns, NJ4 aut |
700 | 1 | a Householder, E4 aut |
700 | 1 | a Taylor-Reinwald, L4 aut |
700 | 1 | a Lee, V4 aut |
700 | 1 | a Korecka, M4 aut |
700 | 1 | a Figurski, M4 aut |
700 | 1 | a Crawford, K4 aut |
700 | 1 | a Neu, S4 aut |
700 | 1 | a Foroud, TM4 aut |
700 | 1 | a Potkin, SG4 aut |
700 | 1 | a Shen, L4 aut |
700 | 1 | a Faber, K4 aut |
700 | 1 | a Kim, S4 aut |
700 | 1 | a Nho, K4 aut |
700 | 1 | a Thal, L4 aut |
700 | 1 | a Buckholtz, N4 aut |
700 | 1 | a Albert, M4 aut |
700 | 1 | a Frank, R4 aut |
700 | 1 | a Hsiao, J4 aut |
700 | 1 | a Kaye, J4 aut |
700 | 1 | a Quinn, J4 aut |
700 | 1 | a Lind, B4 aut |
700 | 1 | a Carter, R4 aut |
700 | 1 | a Dolen, S4 aut |
700 | 1 | a Schneider, LS4 aut |
700 | 1 | a Pawluczyk, S4 aut |
700 | 1 | a Beccera, M4 aut |
700 | 1 | a Teodoro, L4 aut |
700 | 1 | a Spann, BM4 aut |
700 | 1 | a Brewer, J4 aut |
700 | 1 | a Vanderswag, H4 aut |
700 | 1 | a Fleisher, A4 aut |
700 | 1 | a Heidebrink, JL4 aut |
700 | 1 | a Lord, JL4 aut |
700 | 1 | a Mason, SS4 aut |
700 | 1 | a Albers, CS4 aut |
700 | 1 | a Knopman, D4 aut |
700 | 1 | a Johnson, K4 aut |
700 | 1 | a Doody, RS4 aut |
700 | 1 | a Villanueva-Meyer, J4 aut |
700 | 1 | a Chowdhury, M4 aut |
700 | 1 | a Rountree, S4 aut |
700 | 1 | a Dang, M4 aut |
700 | 1 | a Stern, Y4 aut |
700 | 1 | a Honig, LS4 aut |
700 | 1 | a Bell, KL4 aut |
700 | 1 | a Ances, B4 aut |
700 | 1 | a Carroll, M4 aut |
700 | 1 | a Leon, S4 aut |
700 | 1 | a Mintun, MA4 aut |
700 | 1 | a Schneider, S4 aut |
700 | 1 | a Oliver, A4 aut |
700 | 1 | a Marson, D4 aut |
700 | 1 | a Griffith, R4 aut |
700 | 1 | a Clark, D4 aut |
700 | 1 | a Geldmacher, D4 aut |
700 | 1 | a Brockington, J4 aut |
700 | 1 | a Roberson, E4 aut |
700 | 1 | a Grossman, H4 aut |
700 | 1 | a Mitsis, E4 aut |
700 | 1 | a De Toledo-Morrell, L4 aut |
700 | 1 | a Shah, RC4 aut |
700 | 1 | a Duara, R4 aut |
700 | 1 | a Varon, D4 aut |
700 | 1 | a Greig, MT4 aut |
700 | 1 | a Roberts, P4 aut |
700 | 1 | a Onyike, C4 aut |
700 | 1 | a D'Agostino, D4 aut |
700 | 1 | a Kielb, S4 aut |
700 | 1 | a Galvin, JE4 aut |
700 | 1 | a Cerbone, B4 aut |
700 | 1 | a Michel, CA4 aut |
700 | 1 | a Rusinek, H4 aut |
700 | 1 | a de Leon, MJ4 aut |
700 | 1 | a Glodzik, L4 aut |
700 | 1 | a De Santi, S4 aut |
700 | 1 | a Doraiswamy, PM4 aut |
700 | 1 | a Petrella, JR4 aut |
700 | 1 | a Wong, TZ4 aut |
700 | 1 | a Arnold, SE4 aut |
700 | 1 | a Karlawish, JH4 aut |
700 | 1 | a Wolk, D4 aut |
700 | 1 | a Smith, CD4 aut |
700 | 1 | a Jicha, G4 aut |
700 | 1 | a Hardy, P4 aut |
700 | 1 | a Sinha, P4 aut |
700 | 1 | a Oates, E4 aut |
700 | 1 | a Conrad, G4 aut |
700 | 1 | a Lopez, OL4 aut |
700 | 1 | a Oakley, M4 aut |
700 | 1 | a Simpson, DM4 aut |
700 | 1 | a Porsteinsson, AP4 aut |
700 | 1 | a Goldstein, BS4 aut |
700 | 1 | a Martin, K4 aut |
700 | 1 | a Makino, KM4 aut |
700 | 1 | a Ismail, MS4 aut |
700 | 1 | a Brand, C4 aut |
700 | 1 | a Mulnard, RA4 aut |
700 | 1 | a Thai, G4 aut |
700 | 1 | a McAdams-Ortiz, C4 aut |
700 | 1 | a Womack, K4 aut |
700 | 1 | a Mathews, D4 aut |
700 | 1 | a Quiceno, M4 aut |
700 | 1 | a Diaz-Arrastia, R4 aut |
700 | 1 | a King, R4 aut |
700 | 1 | a Weiner, M4 aut |
700 | 1 | a Martin-Cook, K4 aut |
700 | 1 | a DeVous, M4 aut |
700 | 1 | a Levey, AI4 aut |
700 | 1 | a Lah, JJ4 aut |
700 | 1 | a Cellar, JS4 aut |
700 | 1 | a Burns, JM4 aut |
700 | 1 | a Anderson, HS4 aut |
700 | 1 | a Swerdlow, RH4 aut |
700 | 1 | a Apostolova, L4 aut |
700 | 1 | a Tingus, K4 aut |
700 | 1 | a Woo, E4 aut |
700 | 1 | a Silverman, DHS4 aut |
700 | 1 | a Lu, PH4 aut |
700 | 1 | a Bartzokis, G4 aut |
700 | 1 | a Graff-Radford, NR4 aut |
700 | 1 | a Parfitt, F4 aut |
700 | 1 | a Kendall, T4 aut |
700 | 1 | a Johnson, H4 aut |
700 | 1 | a Farlow, MR4 aut |
700 | 1 | a Hake, AM4 aut |
700 | 1 | a Matthews, BR4 aut |
700 | 1 | a Herring, S4 aut |
700 | 1 | a Hunt, C4 aut |
700 | 1 | a Van Dyck, CH4 aut |
700 | 1 | a Carson, RE4 aut |
700 | 1 | a MacAvoy, MG4 aut |
700 | 1 | a Chertkow, H4 aut |
700 | 1 | a Bergman, H4 aut |
700 | 1 | a Hosein, C4 aut |
700 | 1 | a Hsiung, GYR4 aut |
700 | 1 | a Feldman, H4 aut |
700 | 1 | a Mudge, B4 aut |
700 | 1 | a Assaly, M4 aut |
700 | 1 | a Bernick, C4 aut |
700 | 1 | a Munic, D4 aut |
700 | 1 | a Kertesz, A4 aut |
700 | 1 | a Rogers, J4 aut |
700 | 1 | a Trost, D4 aut |
700 | 1 | a Kerwin, D4 aut |
700 | 1 | a Lipowski, K4 aut |
700 | 1 | a Wu, CK4 aut |
700 | 1 | a Johnson, N4 aut |
700 | 1 | a Sadowsky, C4 aut |
700 | 1 | a Martinez, W4 aut |
700 | 1 | a Villena, T4 aut |
700 | 1 | a Turner, RS4 aut |
700 | 1 | a Johnson, K4 aut |
700 | 1 | a Reynolds, B4 aut |
700 | 1 | a Sperling, RA4 aut |
700 | 1 | a Johnson, KA4 aut |
700 | 1 | a Marshall, G4 aut |
700 | 1 | a Frey, M4 aut |
700 | 1 | a Lane, B4 aut |
700 | 1 | a Rosen, A4 aut |
700 | 1 | a Tinklenberg, J4 aut |
700 | 1 | a Sabbagh, MN4 aut |
700 | 1 | a Belden, CM4 aut |
700 | 1 | a Jacobson, SA4 aut |
700 | 1 | a Sirrel, SA4 aut |
700 | 1 | a Kowall, N4 aut |
700 | 1 | a Killiany, R4 aut |
700 | 1 | a Budson, AE4 aut |
700 | 1 | a Norbash, A4 aut |
700 | 1 | a Johnson, PL4 aut |
700 | 1 | a Allard, J4 aut |
700 | 1 | a Lerner, A4 aut |
700 | 1 | a Ogrocki, P4 aut |
700 | 1 | a Hudson, L4 aut |
700 | 1 | a Fletcher, E4 aut |
700 | 1 | a Carmichael, O4 aut |
700 | 1 | a Olichney, J4 aut |
700 | 1 | a DeCarli, C4 aut |
700 | 1 | a Kittur, S4 aut |
700 | 1 | a Borrie, M4 aut |
700 | 1 | a Lee, TY4 aut |
700 | 1 | a Bartha, R4 aut |
700 | 1 | a Johnson, S4 aut |
700 | 1 | a Asthana, S4 aut |
700 | 1 | a Carlsson, CM4 aut |
700 | 1 | a Preda, A4 aut |
700 | 1 | a Nguyen, D4 aut |
700 | 1 | a Tariot, P4 aut |
700 | 1 | a Reeder, S4 aut |
700 | 1 | a Bates, V4 aut |
700 | 1 | a Capote, H4 aut |
700 | 1 | a Rainka, M4 aut |
700 | 1 | a Scharre, DW4 aut |
700 | 1 | a Kataki, M4 aut |
700 | 1 | a Adeli, A4 aut |
700 | 1 | a Zimmerman, EA4 aut |
700 | 1 | a Celmins, D4 aut |
700 | 1 | a Brown, AD4 aut |
700 | 1 | a Pearlson, GD4 aut |
700 | 1 | a Blank, K4 aut |
700 | 1 | a Anderson, K4 aut |
700 | 1 | a Santulli, RB4 aut |
700 | 1 | a Kitzmiller, TJ4 aut |
700 | 1 | a Schwartz, ES4 aut |
700 | 1 | a Sink, KM4 aut |
700 | 1 | a Williamson, JD4 aut |
700 | 1 | a Garg, P4 aut |
700 | 1 | a Watkins, F4 aut |
700 | 1 | a Ott, BR4 aut |
700 | 1 | a Querfurth, H4 aut |
700 | 1 | a Tremont, G4 aut |
700 | 1 | a Salloway, S4 aut |
700 | 1 | a Malloy, P4 aut |
700 | 1 | a Correia, S4 aut |
700 | 1 | a Rosen, HJ4 aut |
700 | 1 | a Miller, BL4 aut |
700 | 1 | a Mintzer, J4 aut |
700 | 1 | a Spicer, K4 aut |
700 | 1 | a Bachman, D4 aut |
700 | 1 | a Pasternak, S4 aut |
700 | 1 | a Rachinsky, I4 aut |
700 | 1 | a Drost, D4 aut |
700 | 1 | a Pomara, N4 aut |
700 | 1 | a Hernando, R4 aut |
700 | 1 | a Sarrael, A4 aut |
700 | 1 | a Schultz, SK4 aut |
700 | 1 | a Ponto, LLB4 aut |
700 | 1 | a Shim, H4 aut |
700 | 1 | a Smith, KE4 aut |
700 | 1 | a Relkin, N4 aut |
700 | 1 | a Chaing, G4 aut |
700 | 1 | a Raudin, L4 aut |
700 | 1 | a Smith, A4 aut |
700 | 1 | a Fargher, K4 aut |
700 | 1 | a Raj, BA4 aut |
700 | 1 | a Neylan, T4 aut |
700 | 1 | a Grafman, J4 aut |
700 | 1 | a Davis, M4 aut |
700 | 1 | a Morrison, R4 aut |
700 | 1 | a Hayes, J4 aut |
700 | 1 | a Finley, S4 aut |
700 | 1 | a Friedl, K4 aut |
700 | 1 | a Fleischman, D4 aut |
700 | 1 | a Arfanakis, K4 aut |
700 | 1 | a James, O4 aut |
700 | 1 | a Massoglia, D4 aut |
700 | 1 | a Fruehling, JJ4 aut |
700 | 1 | a Harding, S4 aut |
700 | 1 | a Peskind, ER4 aut |
700 | 1 | a Petrie, EC4 aut |
700 | 1 | a Li, G4 aut |
700 | 1 | a Yesavage, JA4 aut |
700 | 1 | a Taylor, JL4 aut |
700 | 1 | a Furst, AJ4 aut |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 3310-q 10:1<3310-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-019-10945-z.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141479000 |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-10945-z |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy