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Identification of a...
Identification of a Shared Microbiomic and Metabolomic Profile in Systemic Autoimmune Diseases
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Bellocchi, C (författare)
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Fernandez-Ochoa, A (författare)
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Montanelli, G (författare)
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Vigone, B (författare)
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Santaniello, A (författare)
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Quirantes-Pine, R (författare)
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Borras-Linares, I (författare)
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Gerosa, M (författare)
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Artusi, C (författare)
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Gualtierotti, R (författare)
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Segura-Carrettero, A (författare)
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- Alarcon-Riquelme, ME (författare)
- Karolinska Institutet
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Beretta, L (författare)
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(creator_code:org_t)
- 2019-08-23
- 2019
- Engelska.
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Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 8:9
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Dysbiosis has been described in systemic autoimmune diseases (SADs), including systemic lupus erythematosus (SLE), Sjögren’s syndrome (SjS), and primary anti-phosholipid syndrome (PAPS), however the biological implications of these associations are often elusive. Stool and plasma samples from 114 subjects, including in SLE (n = 27), SjS (n = 23), PAPs (n = 11) and undifferentiated connective tissue (UCTD, n = 26) patients, and geographically-matched healthy controls (HCs, n = 27), were collected for microbiome (16s rRNA gene sequencing) and metabolome (high-performance liquid chromatography coupled to mass spectrometry) analysis to identify shared characteristics across diseases. Out of 130 identified microbial genera, a subset of 29 bacteria was able to differentiate study groups (area under receiver operating characteristics (AUROC) = 0.730 ± 0.025). A fair classification was obtained with a subset of 41 metabolic peaks out of 254 (AUROC = 0.748 ± 0.021). In both models, HCs were well separated from SADs, while UCTD largely overlapped with the other diseases. In all of the SADs pro-tolerogenic bacteria were reduced, while pathobiont genera were increased. Metabolic alterations included two clusters comprised of: (a) members of the acylcarnitine family, positively correlating with a Prevotella-enriched cluster and negatively correlating with a butyrate-producing bacteria-enriched cluster; and (b) phospholipids, negatively correlating with butyrate-producing bacteria. These findings demonstrate a strong interaction between intestinal microbiota and metabolic function in patients with SADs.
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Bellocchi, C
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Fernandez-Ochoa, ...
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Montanelli, G
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Vigone, B
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Santaniello, A
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Quirantes-Pine, ...
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visa fler...
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Borras-Linares, ...
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Gerosa, M
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Artusi, C
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Gualtierotti, R
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Segura-Carretter ...
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Alarcon-Riquelme ...
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Beretta, L
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visa färre...
- Artiklar i publikationen
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Journal of clini ...
- Av lärosätet
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Karolinska Institutet