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Examining the assoc...
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
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Creese, B (författare)
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Vassos, E (författare)
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Bergh, S (författare)
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visa fler...
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Athanasiu, L (författare)
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Johar, I (författare)
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Rongve, A (författare)
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Medboen, IT (författare)
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Da Silva, MV (författare)
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Aakhus, E (författare)
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Andersen, F (författare)
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Bettella, F (författare)
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Braekhus, A (författare)
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Djurovic, S (författare)
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Paroni, G (författare)
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Proitsi, P (författare)
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Saltvedt, I (författare)
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Seripa, D (författare)
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Stordal, E (författare)
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Fladby, T (författare)
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- Aarsland, D (författare)
- Karolinska Institutet
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Andreassen, OA (författare)
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Ballard, C (författare)
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Selbaek, G (författare)
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visa färre...
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(creator_code:org_t)
- 2019-10-22
- 2019
- Engelska.
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 273-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Creese, B
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Vassos, E
-
Bergh, S
-
Athanasiu, L
-
Johar, I
-
Rongve, A
-
visa fler...
-
Medboen, IT
-
Da Silva, MV
-
Aakhus, E
-
Andersen, F
-
Bettella, F
-
Braekhus, A
-
Djurovic, S
-
Paroni, G
-
Proitsi, P
-
Saltvedt, I
-
Seripa, D
-
Stordal, E
-
Fladby, T
-
Aarsland, D
-
Andreassen, OA
-
Ballard, C
-
Selbaek, G
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visa färre...
- Artiklar i publikationen
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Translational ps ...
- Av lärosätet
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Karolinska Institutet