onr:"swepub:oai:prod.swepub.kib.ki.se:142114739"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:142114739" > Examining the assoc...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03218naa a2200529 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:142114739 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1421147392 URI |
| 024 | 7 | a https://doi.org/10.1038/s41398-019-0592-52 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Creese, B4 aut |
| 245 | 1 0 | a Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease |
| 264 | c 2019-10-22 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan. | |
| 700 | 1 | a Vassos, E4 aut |
| 700 | 1 | a Bergh, S4 aut |
| 700 | 1 | a Athanasiu, L4 aut |
| 700 | 1 | a Johar, I4 aut |
| 700 | 1 | a Rongve, A4 aut |
| 700 | 1 | a Medboen, IT4 aut |
| 700 | 1 | a Da Silva, MV4 aut |
| 700 | 1 | a Aakhus, E4 aut |
| 700 | 1 | a Andersen, F4 aut |
| 700 | 1 | a Bettella, F4 aut |
| 700 | 1 | a Braekhus, A4 aut |
| 700 | 1 | a Djurovic, S4 aut |
| 700 | 1 | a Paroni, G4 aut |
| 700 | 1 | a Proitsi, P4 aut |
| 700 | 1 | a Saltvedt, I4 aut |
| 700 | 1 | a Seripa, D4 aut |
| 700 | 1 | a Stordal, E4 aut |
| 700 | 1 | a Fladby, T4 aut |
| 700 | 1 | a Aarsland, Du Karolinska Institutet4 aut |
| 700 | 1 | a Andreassen, OA4 aut |
| 700 | 1 | a Ballard, C4 aut |
| 700 | 1 | a Selbaek, G4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Translational psychiatryd : Springer Science and Business Media LLCg 9:1, s. 273-q 9:1<273-x 2158-3188 |
| 856 | 4 | u https://www.nature.com/articles/s41398-019-0592-5.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142114739 |
| 856 | 4 8 | u https://doi.org/10.1038/s41398-019-0592-5 |
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