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Different epigeneti...
Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis
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Theodoropoulou, E (författare)
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- Alfredsson, L (författare)
- Karolinska Institutet
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- Piehl, F (författare)
- Karolinska Institutet
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- Marabita, F (författare)
- Karolinska Institutet
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- Jagodic, M (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Future Medicine Ltd, 2019
- 2019
- Engelska.
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Ingår i: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 11:12, s. 1429-1439
- Relaterad länk:
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https://doi.org/10.2...
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http://kipublication...
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https://doi.org/10.2...
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Abstract
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- Aim: Accumulating evidence links epigenetic age to diseases and age-related conditions, but little is known about its association with multiple sclerosis (MS). Materials & methods: We estimated epigenetic age acceleration measures using DNA methylation from blood or sorted cells of MS patients and controls. Results: In blood, sex (p = 4.39E-05) and MS (p = 2.99E-03) explained the variation in age acceleration, and isolated blood cell types showed different epigenetic age. Intrinsic epigenetic age acceleration and extrinsic epigenetic age acceleration were only associated with sex (p = 2.52E-03 and p = 1.58E-04, respectively), while PhenoAge Acceleration displayed positive association with MS (p = 3.40E-02). Conclusion: Different age acceleration measures are distinctly influenced by phenotypic factors, and they might measure separate pathophysiological aspects of MS. Data deposition: DNA methylation data can be accessed at Gene Expression Omnibus database under accession number GSE35069, GSE43976, GSE106648, GSE130029, GSE130030.
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- art (ämneskategori)
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