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CD155: A Multi-Func...
CD155: A Multi-Functional Molecule in Tumor Progression
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Molfetta, R (författare)
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- Zitti, B (författare)
- Karolinska Institutet
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Lecce, M (författare)
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Milito, ND (författare)
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Stabile, H (författare)
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Fionda, C (författare)
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Cippitelli, M (författare)
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Gismondi, A (författare)
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Santoni, A (författare)
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Paolini, R (författare)
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(creator_code:org_t)
- 2020-01-30
- 2020
- Engelska.
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Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 21:3
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on cytotoxic lymphocytes including Natural Killer (NK) cells and involved in anti-tumor immune response. However, during tumor progression inhibitory receptors for CD155 are up-regulated on the surface of effector cells, contributing to an impairment of their cytotoxic capacity. In this review we will focus on the roles of CD155 as a ligand for the activating receptor DNAM-1 regulating immune surveillance against cancer and as pro-oncogenic molecule favoring tumor proliferation, invasion and immune evasion. A deeper understanding of the multiple roles played by CD155 in cancer development contributes to improving anti-tumor strategies aimed to potentiate immune response against cancer.
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- Av författaren/redakt...
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Molfetta, R
-
Zitti, B
-
Lecce, M
-
Milito, ND
-
Stabile, H
-
Fionda, C
-
visa fler...
-
Cippitelli, M
-
Gismondi, A
-
Santoni, A
-
Paolini, R
-
visa färre...
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- Av lärosätet
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Karolinska Institutet