Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:144208592" > Chronic Viral Liver...
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000 | 01982naa a2200337 4500 | |
001 | oai:prod.swepub.kib.ki.se:144208592 | |
003 | SwePub | |
008 | 240913s2020 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442085922 URI |
024 | 7 | a https://doi.org/10.3390/cells90614712 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Healy, K4 aut |
245 | 1 0 | a Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies |
264 | c 2020-06-16 | |
264 | 1 | b MDPI AG,c 2020 |
520 | a Chronic infection with viral hepatitis is a major risk factor for liver injury and hepatocellular carcinoma (HCC). One major contributing factor to the chronicity is the dysfunction of virus-specific T cell immunity. T cells engineered to express virus-specific T cell receptors (TCRs) may be a therapeutic option to improve host antiviral responses and have demonstrated clinical success against virus-associated tumours. This review aims to give an overview of TCRs identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field. TCR isolation pipelines, liver homing signals, cell type options, as well as safety considerations will be discussed herein. | |
700 | 1 | a Pasetto, Au Karolinska Institutet4 aut |
700 | 1 | a Sobkowiak, MJu Karolinska Institutet4 aut |
700 | 1 | a Soon, CF4 aut |
700 | 1 | a Cornberg, M4 aut |
700 | 1 | a Aleman, Su Karolinska Institutet4 aut |
700 | 1 | a Chen, MSu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Cellsd : MDPI AGg 9:6q 9:6x 2073-4409 |
856 | 4 | u https://www.mdpi.com/2073-4409/9/6/1471/pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144208592 |
856 | 4 8 | u https://doi.org/10.3390/cells9061471 |
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