Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:144486580" > The genetic archite...
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000 | 07847naa a2201573 4500 | |
001 | oai:prod.swepub.kib.ki.se:144486580 | |
003 | SwePub | |
008 | 240811s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-174902 | |
009 | oai:DiVA.org:uu-440787 | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1444865802 URI |
024 | 7 | a https://doi.org/10.1038/s41467-020-17376-12 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1749022 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4407872 URI |
040 | a (SwePub)kid (SwePub)umud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Elvsashagen, T4 aut |
245 | 1 0 | a The genetic architecture of human brainstem structures and their involvement in common brain disorders |
264 | c 2020-08-11 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
520 | a Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Bahrami, S4 aut |
700 | 1 | a van der Meer, D4 aut |
700 | 1 | a Agartz, Iu Karolinska Institutet4 aut |
700 | 1 | a Alnaes, D4 aut |
700 | 1 | a Barch, DM4 aut |
700 | 1 | a Baur-Streubel, R4 aut |
700 | 1 | a Bertolino, A4 aut |
700 | 1 | a Beyer, MK4 aut |
700 | 1 | a Blasi, G4 aut |
700 | 1 | a Borgwardt, S4 aut |
700 | 1 | a Boye, B4 aut |
700 | 1 | a Buitelaar, J4 aut |
700 | 1 | a Boen, E4 aut |
700 | 1 | a Celius, EGu Karolinska Institutet4 aut |
700 | 1 | a Cervenka, Simonu Karolinska Institutet,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden4 aut0 (Swepub:uu)simce160 |
700 | 1 | a Conzelmann, A4 aut |
700 | 1 | a Coynel, D4 aut |
700 | 1 | a Di Carlo, P4 aut |
700 | 1 | a Djurovic, S4 aut |
700 | 1 | a Eisenacher, S4 aut |
700 | 1 | a Espeseth, T4 aut |
700 | 1 | a Fatouros-Bergman, Hu Karolinska Institutet4 aut |
700 | 1 | a Flyckt, Lu Karolinska Institutet4 aut |
700 | 1 | a Franke, B4 aut |
700 | 1 | a Frei, Ou Karolinska Institutet4 aut |
700 | 1 | a Gelao, B4 aut |
700 | 1 | a Harbo, HF4 aut |
700 | 1 | a Hartman, CA4 aut |
700 | 1 | a Haberg, A4 aut |
700 | 1 | a Heslenfeld, D4 aut |
700 | 1 | a Hoekstra, PJ4 aut |
700 | 1 | a Hogestol, EA4 aut |
700 | 1 | a Jonassen, R4 aut |
700 | 1 | a Jonsson, EGu Karolinska Institutet4 aut |
700 | 1 | a Kirsch, P4 aut |
700 | 1 | a Kloszewska, I4 aut |
700 | 1 | a Lagerberg, TV4 aut |
700 | 1 | a Landro, NI4 aut |
700 | 1 | a Le Hellard, Su Karolinska Institutet4 aut |
700 | 1 | a Lesch, KP4 aut |
700 | 1 | a Maglanoc, LA4 aut |
700 | 1 | a Malt, UF4 aut |
700 | 1 | a Mecocci, P4 aut |
700 | 1 | a Melle, I4 aut |
700 | 1 | a Meyer-Lindenberg, A4 aut |
700 | 1 | a Moberget, T4 aut |
700 | 1 | a Nordvik, JE4 aut |
700 | 1 | a Nyberg, Lars,d 1966-u Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001 |
700 | 1 | a O'Connell, KS4 aut |
700 | 1 | a Oosterlaan, J4 aut |
700 | 1 | a Papalino, M4 aut |
700 | 1 | a Papassotiropoulos, A4 aut |
700 | 1 | a Pauli, P4 aut |
700 | 1 | a Pergola, G4 aut |
700 | 1 | a Persson, K4 aut |
700 | 1 | a de Quervain, D4 aut |
700 | 1 | a Reif, A4 aut |
700 | 1 | a Rokicki, J4 aut |
700 | 1 | a van Rooij, D4 aut |
700 | 1 | a Shadrin, AA4 aut |
700 | 1 | a Schmidt, A4 aut |
700 | 1 | a Schwarz, E4 aut |
700 | 1 | a Selbaek, G4 aut |
700 | 1 | a Soininen, H4 aut |
700 | 1 | a Sowa, P4 aut |
700 | 1 | a Steen, VM4 aut |
700 | 1 | a Tsolaki, M4 aut |
700 | 1 | a Vellas, B4 aut |
700 | 1 | a Wang, L4 aut |
700 | 1 | a Westman, Eu Karolinska Institutet4 aut |
700 | 1 | a Ziegler, GC4 aut |
700 | 1 | a Zink, M4 aut |
700 | 1 | a Andreassen, OA4 aut |
700 | 1 | a Westlye, LT4 aut |
700 | 1 | a Kaufmann, T4 aut |
700 | 1 | a Farde, Lu Karolinska Institutet4 aut |
700 | 1 | a Flyckt, Lu Karolinska Institutet4 aut |
700 | 1 | a Engberg, Gu Karolinska Institutet4 aut |
700 | 1 | a Erhardt, SS4 aut |
700 | 1 | a Fatouros-Bergman, Hu Karolinska Institutet4 aut |
700 | 1 | a Cervenka, Su Karolinska Institutet4 aut |
700 | 1 | a Schwieler, Lu Karolinska Institutet4 aut |
700 | 1 | a Piehl, Fu Karolinska Institutet4 aut |
700 | 1 | a Agartz, Iu Karolinska Institutet4 aut |
700 | 1 | a Collste, K4 aut |
700 | 1 | a Victorsson, P4 aut |
700 | 1 | a Malmqvist, Au Karolinska Institutet4 aut |
700 | 1 | a Hedberg, M4 aut |
700 | 1 | a Orhan, Fu Karolinska Institutet4 aut |
700 | 1 | a Sellgren, CMu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 11:1, s. 4016-q 11:1<4016-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-020-17376-1.pdf |
856 | 4 | u https://doi.org/10.1038/s41467-020-17376-1y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1466941/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1545984/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144486580 |
856 | 4 8 | u https://doi.org/10.1038/s41467-020-17376-1 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174902 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440787 |
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