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Surgery in Nasal Po...
Surgery in Nasal Polyp Patients: Outcome After a Minimum Observation of 10 Years
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Vlaminck, S (författare)
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Acke, F (författare)
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Prokopakis, E (författare)
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Speleman, K (författare)
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Kawauchi, H (författare)
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van Cutsem, JC (författare)
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Hellings, PW (författare)
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Jorissen, M (författare)
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Seys, S (författare)
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- Bachert, C (författare)
- Karolinska Institutet
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Van Zele, T (författare)
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Lambrecht, BN (författare)
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Gevaert, P (författare)
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(creator_code:org_t)
- 2020-10-05
- 2021
- Engelska.
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Ingår i: American journal of rhinology & allergy. - : SAGE Publications. - 1945-8932 .- 1945-8924. ; 35:4, s. 449-457
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Chronic rhinosinusitis with nasal polyps (CRSwNP) often requires surgery, but recurrence even after surgery is common. Recurrence rates largely vary in literature and asthma seems to be a comorbid factor. Objective In this study, we aim to estimate disease recurrence during a long-term follow-up, together with the investigation of possible predicting and/or influencing parameters. Methods Out of 196 patients operated for CRSwNP between 01/2000 and 01/2006, 133 patients had a follow-up of at least 10 years and could be included. The inflammatory profile at surgery was determined on nasal tissue and sinonasal secretions, and included analysis of eosinophils, eosinophilic-rich mucus (ERM) typically containing Charcot-Leyden crystals (CLC), and fungal hyphae (FH). During follow-up, recurrence, received treatments and comorbidities were collected. Results Out of the 133 included patients, local eosinophilia was present in 81% and ERM in 60%. Recurrence during follow-up was observed in 62%, and was associated with local eosinophilia and ERM (both p < 0.001). Asthma was present in 28% at inclusion, and 17% developed asthma after surgery during follow-up. The presence of asthma, at inclusion as well as developed during follow-up, was significantly associated with recurrence of CRSwNP (p = 0.001 for group comparison). Conclusion Recurrence after CRSwNP surgery is common when a long-term follow-up is taken into account. ERM detected in sinonasal secretions at surgery seems to be a predictive factor for recurrence and need for revision surgery. Asthma is a frequently found comorbid factor in CRSwNP, develops even at higher age despite surgical treatment for CRSwNP, and is also associated with a higher recurrence rate. Sustained medical care after surgery is mandatory.
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Vlaminck, S
-
Acke, F
-
Prokopakis, E
-
Speleman, K
-
Kawauchi, H
-
van Cutsem, JC
-
visa fler...
-
Hellings, PW
-
Jorissen, M
-
Seys, S
-
Bachert, C
-
Van Zele, T
-
Lambrecht, BN
-
Gevaert, P
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visa färre...
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American journal ...
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Karolinska Institutet