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Vitamin C and E Tre...
Vitamin C and E Treatment Blunts Sprint Interval Training-Induced Changes in Inflammatory Mediator-, Calcium-, and Mitochondria-Related Signaling in Recreationally Active Elderly Humans
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Wyckelsma, VL (författare)
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Venckunas, T (författare)
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Brazaitis, M (författare)
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visa fler...
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- Gastaldello, S (författare)
- Karolinska Institutet
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Snieckus, A (författare)
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Eimantas, N (författare)
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Baranauskiene, N (författare)
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Subocius, A (författare)
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Skurvydas, A (författare)
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Paasuke, M (författare)
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Gapeyeva, H (författare)
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Kaasik, P (författare)
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Paasuke, R (författare)
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Jurimae, J (författare)
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Graf, BA (författare)
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Kayser, B (författare)
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Place, N (författare)
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- Andersson, DC (författare)
- Karolinska Institutet
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Kamandulis, S (författare)
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- Westerblad, H (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-09-17
- 2020
- Engelska.
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Ingår i: Antioxidants (Basel, Switzerland). - : MDPI AG. - 2076-3921. ; 9:9
- Relaterad länk:
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https://doi.org/10.3...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Sprint interval training (SIT) has emerged as a time-efficient training regimen for young individuals. Here, we studied whether SIT is effective also in elderly individuals and whether the training response was affected by treatment with the antioxidants vitamin C and E. Recreationally active elderly (mean age 65) men received either vitamin C (1 g/day) and vitamin E (235 mg/day) or placebo. Training consisted of nine SIT sessions (three sessions/week for three weeks of 4-6 repetitions of 30-s all-out cycling sprints) interposed by 4 min rest. Vastus lateralis muscle biopsies were taken before, 1 h after, and 24 h after the first and last SIT sessions. At the end of the three weeks of training, SIT-induced changes in relative mRNA expression of reactive oxygen/nitrogen species (ROS)- and mitochondria-related proteins, inflammatory mediators, and the sarcoplasmic reticulum Ca2+ channel, the ryanodine receptor 1 (RyR1), were blunted in the vitamin treated group. Western blots frequently showed a major (>50%) decrease in the full-length expression of RyR1 24 h after SIT sessions; in the trained state, vitamin treatment seemed to provide protection against this severe RyR1 modification. Power at exhaustion during an incremental cycling test was increased by ~5% at the end of the training period, whereas maximal oxygen uptake remained unchanged; vitamin treatment did not affect these measures. In conclusion, treatment with the antioxidants vitamin C and E blunts SIT-induced cellular signaling in skeletal muscle of elderly individuals, while the present training regimen was too short or too intense for the changes in signaling to be translated into a clear-cut change in physical performance.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wyckelsma, VL
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Venckunas, T
-
Brazaitis, M
-
Gastaldello, S
-
Snieckus, A
-
Eimantas, N
-
visa fler...
-
Baranauskiene, N
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Subocius, A
-
Skurvydas, A
-
Paasuke, M
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Gapeyeva, H
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Kaasik, P
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Paasuke, R
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Jurimae, J
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Graf, BA
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Kayser, B
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Place, N
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Andersson, DC
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Kamandulis, S
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Westerblad, H
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visa färre...
- Artiklar i publikationen
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Antioxidants (Ba ...
- Av lärosätet
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Karolinska Institutet