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The Association bet...
The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:146239005
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146239005URI
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https://doi.org/10.3390/biomedicines9030286DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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The impact of cholesteryl ester transfer protein (CETP) on atherosclerosis is highly debated. This study aimed to investigate the associations between plasma CETP or CETP genotypes and carotid intima-media thickness (cIMT) and the influence of high-density lipoprotein cholesterol (HDL-C) on these associations. Plasma CETP and HDL-C concentrations were measured in 552 subjects free of any pharmacological treatment from the IMPROVE cohort, which includes 3711 European subjects at high cardiovascular risk. CETP single-nucleotide polymorphisms (SNPs) and cIMT measures (cIMTmax; cIMTmean–max of bifurcations, common and internal carotids; plaque-free common carotid [PF CC]-IMTmean) were available for the full cohort. In drug-free subjects, plasma CETP correlated with HDL-C levels (r = 0.19, p < 0.0001), but not with cIMT variables. When stratified according to HDL-C quartiles, CETP positively correlated with cIMTmax and cIMTmean–max, but not with PF CC-IMTmean, in the top HDL-C quartile only. Positive associations between the CETP concentration and cIMTmax or cIMTmean–max were found in the top HDL-C quartile, whereas HDL-C levels were negatively correlated with cIMTmax and cIMTmean–max when the CETP concentration was below the median (HDL-C × CETP interaction, p = 0.001 and p = 0.003 for cIMTmax and cIMTmean–max, respectively). In the full cohort, three CETP SNPs (rs34760410, rs12920974, rs12708968) were positively associated with cIMTmax. rs12444708 exhibited a significant interaction with HDL-C levels in the prediction of cIMTmax. In conclusion, a significant interplay was found between plasma CETP and/or CETP genotype and HDL-C in the prediction of carotid plaque thickness, as indexed by cIMTmax. This suggests that the association of HDL-C with carotid atherosclerosis is CETP-dependent.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bianconi, V
(författare)
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Bonomi, A
(författare)
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Simonelli, S
(författare)
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Amato, M
(författare)
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Frigerio, B
(författare)
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Ravani, A
(författare)
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Vitali, C
(författare)
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Sansaro, D
(författare)
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Coggi, D
(författare)
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Mannarino, MR
(författare)
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Savonen, KP
(författare)
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Kurl, S
(författare)
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Gigante, BKarolinska Institutet
(författare)
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Smit, AJ
(författare)
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Giral, P
(författare)
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Tremoli, E
(författare)
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Calabresi, L
(författare)
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Veglia, F
(författare)
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Pirro, M
(författare)
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Baldassarre, D
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biomedicines: MDPI AG9:32227-9059
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Colombo, GI
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Bianconi, V
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Bonomi, A
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Simonelli, S
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Amato, M
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Frigerio, B
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visa fler...
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Ravani, A
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Vitali, C
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Sansaro, D
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Coggi, D
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Mannarino, MR
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Savonen, KP
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Kurl, S
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Gigante, B
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Smit, AJ
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Giral, P
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Tremoli, E
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Calabresi, L
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Veglia, F
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Pirro, M
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Baldassarre, D
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visa färre...
- Artiklar i publikationen
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Biomedicines
- Av lärosätet
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Karolinska Institutet