Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:146288456" >
Cytokine Profiling ...
Cytokine Profiling of End Stage Cancer Patients Treated with Immunotherapy
-
Merlano, MC (författare)
-
Abbona, A (författare)
-
Paccagnella, M (författare)
-
visa fler...
-
Falletta, A (författare)
-
Granetto, C (författare)
-
Ricci, V (författare)
-
Fea, E (författare)
-
Denaro, N (författare)
-
Ruatta, F (författare)
-
Merlotti, A (författare)
-
Bertetto, O (författare)
-
- Crosetto, N (författare)
- Karolinska Institutet
-
Galizia, D (författare)
-
Basirico, M (författare)
-
Gammaitoni, L (författare)
-
Sangiolo, D (författare)
-
Aglietta, M (författare)
-
Garrone, O (författare)
-
visa färre...
-
(creator_code:org_t)
- 2021-03-08
- 2021
- Engelska.
-
Ingår i: Vaccines. - : MDPI AG. - 2076-393X. ; 9:3
- Relaterad länk:
-
https://www.mdpi.com...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Published data suggest that immunotherapy plays a role even in patients with very advanced tumours. We investigated the immune profile of end-stage cancer patients treated with immunotherapy to identify changes induced by treatment. Breast, colon, renal and prostate cancer patients were eligible. Treatment consisted of metronomic cyclophosphamide, low-dose interleukin-2 (IL-2) and a single radiation shot. A panel of 16 cytokines was assessed using automated ELISA before treatment (T0), after radiation (RT; T1), at cycle 2 (T2) and at disease progression (TPD). Receiving operating characteristic (ROC) analysis was used to identify cytokine cut-off related to overall survival (OS). Principal component analysis (PCA) was used to identify the immune profile correlating better with OS and progression-free survival. Twenty-three patients were enrolled. High IL-2, low IL-8 and CCL-2 correlated with OS. The PCA identified a cluster of patients, with high IL-2, IL-12 and IFN-γ levels at T0 having longer PFS and OS. In all cohorts, IL-2 and IL-5 increased from T0 to T2; a higher CCL-4 level compared to T2 and a higher IL-8 level compared to T0 were found at TPD. The progressive increase of the IL-10 level during treatment negatively correlated with OS. Our data suggested that baseline cytokine levels may predict patients’ outcome and that the treatment may affect their kinetic even in end-stage patients. Cytokine profiling of end-stage patients might offer a tool for medical decisions (EUDRACT: 2016-000578-39).
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Vaccines
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Merlano, MC
-
Abbona, A
-
Paccagnella, M
-
Falletta, A
-
Granetto, C
-
Ricci, V
-
visa fler...
-
Fea, E
-
Denaro, N
-
Ruatta, F
-
Merlotti, A
-
Bertetto, O
-
Crosetto, N
-
Galizia, D
-
Basirico, M
-
Gammaitoni, L
-
Sangiolo, D
-
Aglietta, M
-
Garrone, O
-
visa färre...
- Artiklar i publikationen
-
Vaccines
- Av lärosätet
-
Karolinska Institutet