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Short-term IL-15 pr...
Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch
- Artikel/kapitelEngelska2021
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2021-02-16
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Life Science Alliance, LLC,2021
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:146693920
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146693920URI
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https://doi.org/10.26508/lsa.202000723DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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IL-15 priming of NK cells is a broadly accepted concept, but the dynamics and underlying molecular mechanisms remain poorly understood. We show that as little as 5 min of IL-15 treatment in vitro, followed by removal of excess cytokines, results in a long-lasting, but reversible, augmentation of NK cell responsiveness upon activating receptor cross-linking. In contrast to long-term stimulation, improved NK cell function after short-term IL-15 priming was not associated with enhanced metabolism but was based on the increased steady-state phosphorylation level of signalling molecules downstream of activating receptors. Inhibition of JAK3 eliminated this priming effect, suggesting a cross talk between the IL-15 receptor and ITAM-dependent activating receptors. Increased signalling molecule phosphorylation levels, calcium flux, and IFN-γ secretion lasted for up to 3 h after IL-15 stimulation before returning to baseline. We conclude that IL-15 rapidly and reversibly primes NK cell function by modulating activating receptor signalling. Our findings suggest a mechanism by which NK cell reactivity can potentially be maintained in vivo based on only brief encounters with IL-15 trans-presenting cells.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Schmied, L
(författare)
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Nguyen, NA
(författare)
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Wiel, C
(författare)
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Meinke, SKarolinska Institutet
(författare)
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Mohammad, DKKarolinska Institutet
(författare)
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Bergo, MKarolinska Institutet
(författare)
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Alici, EKarolinska Institutet
(författare)
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Kadri, NKarolinska Institutet
(författare)
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Ganesan, S
(författare)
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Hoglund, PKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Life science alliance: Life Science Alliance, LLC4:42575-1077
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Till lärosätets databas
- Av författaren/redakt...
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Luu, TT
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Schmied, L
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Nguyen, NA
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Wiel, C
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Meinke, S
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Mohammad, DK
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visa fler...
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Bergo, M
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Alici, E
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Kadri, N
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Ganesan, S
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Hoglund, P
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visa färre...
- Artiklar i publikationen
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Life science all ...
- Av lärosätet
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Karolinska Institutet