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Enhanced virulence ...
Enhanced virulence of Plasmodium falciparum in blood of diabetic patients
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Ch'ng, JH (författare)
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- Moll, K (författare)
- Karolinska Institutet
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- Wyss, K (författare)
- Karolinska Institutet
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Hammar, U (författare)
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- Ryden, M (författare)
- Karolinska Institutet
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- Kampe, O (författare)
- Karolinska Institutet
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- Farnert, A (författare)
- Karolinska Institutet
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Wahlgren, M (författare)
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(creator_code:org_t)
- 2021-06-17
- 2021
- Engelska.
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 16:6, s. e0249666-
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https://journals.plo...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus (T2DM) infected with Plasmodium falciparum were three times more likely to develop severe malaria than non-diabetics. Here we explore the biological basis for this by testing blood from uninfected subjects with type 1 and type 2 diabetes, ex vivo, for their effects on parasite growth and rosetting (binding of infected erythrocytes to uninfected erythrocytes). Rosetting was associated with type 2 diabetes, blood glucose and erythrocyte sedimentation rate (ESR), while parasite growth was positively associated with blood glucose, glycated hemoglobin (HbA1c), body mass index (BMI), fibrinogen and triglycerides. This study establishes a link between diabetes and malaria virulence assays, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes.
Publikations- och innehållstyp
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- art (ämneskategori)
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PloS one
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