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Early treatment del...
Early treatment delays long-term disability accrual in RRMS: Results from the BMSD network
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Iaffaldano, P (författare)
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Lucisano, G (författare)
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Butzkueven, H (författare)
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- Hillert, J (författare)
- Karolinska Institutet
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Hyde, R (författare)
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Koch-Henriksen, N (författare)
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Magyari, M (författare)
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Pellegrini, F (författare)
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Spelman, T (författare)
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Sorensen, PS (författare)
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Vukusic, S (författare)
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Trojano, M (författare)
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(creator_code:org_t)
- 2021-04-26
- 2021
- Engelska.
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 27:10, s. 1543-1555
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The optimal timing of treatment starts for achieving the best control on the long-term disability accumulation in multiple sclerosis (MS) is still to be defined. Objective: The aim of this study was to estimate the optimal time to start disease-modifying therapies (DMTs) to prevent the long-term disability accumulation in MS, using a pooled dataset from the Big Multiple Sclerosis Data (BMSD) network. Methods: Multivariable Cox regression models adjusted for the time to first treatment start from disease onset (in quintiles) were used. To mitigate the impact of potential biases, a set of pairwise propensity score (PS)-matched analyses were performed. The first quintile, including patients treated within 1.2 years from onset, was used as reference. Results: A cohort of 11,871 patients (median follow-up after treatment start: 13.2 years) was analyzed. A 3- and 12-month confirmed disability worsening event and irreversible Expanded Disability Status Scale (EDSS) 4.0 and 6.0 scores were reached by 7062 (59.5%), 4138 (34.9%), 3209 (31.1%), and 1909 (16.5%) patients, respectively. The risk of reaching all the disability outcomes was significantly lower ( p < 0.0004) for the first quintile patients’ group. Conclusion: Real-world data from the BMSD demonstrate that DMTs should be commenced within 1.2 years from the disease onset to reduce the risk of disability accumulation over the long term.
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- Av författaren/redakt...
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Iaffaldano, P
-
Lucisano, G
-
Butzkueven, H
-
Hillert, J
-
Hyde, R
-
Koch-Henriksen, ...
-
visa fler...
-
Magyari, M
-
Pellegrini, F
-
Spelman, T
-
Sorensen, PS
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Vukusic, S
-
Trojano, M
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visa färre...
- Artiklar i publikationen
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Multiple scleros ...
- Av lärosätet
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Karolinska Institutet