onr:"swepub:oai:prod.swepub.kib.ki.se:147338276"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:147338276" > Decidualized endome...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02851naa a2200409 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147338276 | |
| 003 | SwePub | |
| 008 | 240902s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1473382762 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-021-95705-02 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Khatun, M4 aut |
| 245 | 1 0 | a Decidualized endometrial stromal cells present with altered androgen response in PCOS |
| 264 | c 2021-08-11 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS endometrial stromal cells (eSCCtrl); however, this has not been assessed in PCOS cells (eSCPCOS). Therefore, we studied the transcriptome profile of non-decidualized (non-DE) and DE eSCs from women with PCOS and Ctrl in response to short-term estradiol (E2) and/or progesterone (P4) exposure with/without (±) DHT. The non-DE eSCs were subjected to E2 ± DHT treatment, whereas the DE (0.5 mM 8-Br-cAMP, 96 h) eSCs were post-treated with E2 and P4 ± DHT, and RNA-sequenced. Validation was performed by immunofluorescence and immunohistochemistry. The results showed that, regardless of treatment, the PCOS and Ctrl samples clustered separately. The comparison of DE vs. non-DE eSCPCOS without DHT revealed PCOS-specific differentially expressed genes (DEGs) involved in mitochondrial function and progesterone signaling. When further adding DHT, we detected altered responses for lysophosphatidic acid (LPA), inflammation, and androgen signaling. Overall, the results highlight an underlying defect in decidualized eSCPCOS, present with or without DHT exposure, and possibly linked to the altered pregnancy outcomes. We also report novel factors which elucidate the mechanisms of endometrial dysfunction in PCOS. | |
| 700 | 1 | a Meltsov, A4 aut |
| 700 | 1 | a Lavogina, D4 aut |
| 700 | 1 | a Loid, M4 aut |
| 700 | 1 | a Kask, K4 aut |
| 700 | 1 | a Arffman, RK4 aut |
| 700 | 1 | a Rossi, HR4 aut |
| 700 | 1 | a Lattekivi, F4 aut |
| 700 | 1 | a Jaager, K4 aut |
| 700 | 1 | a Krjutskov, K4 aut |
| 700 | 1 | a Rinken, A4 aut |
| 700 | 1 | a Salumets, Au Karolinska Institutet4 aut |
| 700 | 1 | a Piltonen, TT4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 11:1, s. 16287-q 11:1<16287-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-021-95705-0.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147338276 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-021-95705-0 |
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