Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:147851564" >
Endurance exercise ...
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism
-
Massart, J (författare)
-
Sjogren, RJO (författare)
-
Egan, B (författare)
-
visa fler...
-
Garde, C (författare)
-
Lindgren, M (författare)
-
Gu, WF (författare)
-
- Ferreira, DMS (författare)
- Karolinska Institutet
-
Katayama, M (författare)
-
- Ruas, JL (författare)
- Karolinska Institutet
-
Barres, R (författare)
-
O'Gorman, DJ (författare)
-
- Zierath, JR (författare)
- Karolinska Institutet
-
- Krook, A (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2021-10-12
- 2021
- Engelska.
-
Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 5948-
- Relaterad länk:
-
https://www.nature.c...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training regime. Among the exercise training-responsive miRNAs identified, miR-19b-3p was selected for further validation. Overexpression of miR-19b-3p in human skeletal muscle cells increases insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training. Overexpression of miR-19b-3p in mouse flexor digitorum brevis muscle enhances contraction-induced glucose uptake, indicating that miR-19b-3p exerts control on exercise training-induced adaptations in skeletal muscle. Potential targets of miR-19b-3p that are reduced after aerobic exercise training include KIF13A, MAPK6, RNF11, and VPS37A. Amongst these, RNF11 silencing potentiates glucose uptake in human skeletal muscle cells. Collectively, we identify miR-19b-3p as an aerobic exercise training-induced miRNA that regulates skeletal muscle glucose metabolism.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Massart, J
-
Sjogren, RJO
-
Egan, B
-
Garde, C
-
Lindgren, M
-
Gu, WF
-
visa fler...
-
Ferreira, DMS
-
Katayama, M
-
Ruas, JL
-
Barres, R
-
O'Gorman, DJ
-
Zierath, JR
-
Krook, A
-
visa färre...
- Artiklar i publikationen
-
Nature communica ...
- Av lärosätet
-
Karolinska Institutet