onr:"swepub:oai:prod.swepub.kib.ki.se:148164275"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02743naa a2200337 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:148164275 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1481642752 URI |
| 024 | 7 | a https://doi.org/10.3390/jcdd81101432 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ntika, Su Karolinska Institutet4 aut |
| 245 | 1 0 | a Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes |
| 264 | c 2021-10-28 | |
| 264 | 1 | b MDPI AG,c 2021 |
| 520 | a Glucagon-like peptide-1 (GLP-1) regulates processes involved in the pathophysiology of thoracic aortic aneurysms (TAAs), including inflammation, while protecting against aortic aneurysms in animal models. Type 2 diabetes (T2D) involves altered GLP-1 signaling due to pathology and/or therapy and is associated with reduced prevalence of TAAs. We aimed to assess whether T2D alters the inflammatory profile/proteolytic activity, possible correlations to elevated fasting GLP-1 (F-GLP-1), and its relevance for TAA. F-GLP-1, pro-inflammatory T helper 1 (Th1) cytokines, Th2 cytokines, C-reactive protein, and matrix metalloproteinase-2 activity (MMP-2) were analyzed in surgical patients with aortic valve pathology with/without T2D and without T2D but with TAA. Patients with T2D displayed an increase in the relative systemic expression of interleukin 6 and tumor necrosis factor α and a clear trend towards reduced levels of interferon γ (IFNγ). In addition, a positive association between GLP-1 and the plasma interleukin 4 (IL-4)/IFNγ ratio was detected. TAA was associated with significantly lower plasma levels of the Th2 cytokines IL-4 and interleukin 5. Plasma MMP-2 activity did not differ between groups. We conclude that T2D involved a Th2 shift, which associates with elevated F-GLP-1 and may—considering Th1 bias in TAA—contribute to reduced prevalence of TAA in T2D. | |
| 700 | 1 | a Jois, H4 aut |
| 700 | 1 | a Lang, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Olsson, Cu Karolinska Institutet4 aut |
| 700 | 1 | a Franco-Cereceda, Au Karolinska Institutet4 aut |
| 700 | 1 | a Bjorck, HMu Karolinska Institutet4 aut |
| 700 | 1 | a Krizhanovskii, C4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Journal of cardiovascular development and diseased : MDPI AGg 8:11q 8:11x 2308-3425 |
| 856 | 4 | u https://www.mdpi.com/2308-3425/8/11/143/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148164275 |
| 856 | 4 8 | u https://doi.org/10.3390/jcdd8110143 |
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