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Trans-Ned 19-Mediat...
Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice
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Nawrocki, M (författare)
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Lory, N (författare)
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Bedke, T (författare)
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Stumme, F (författare)
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Diercks, BP (författare)
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Guse, AH (författare)
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Meier, C (författare)
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- Gagliani, N (författare)
- Karolinska Institutet
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Mittruecker, HW (författare)
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Huber, S (författare)
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(creator_code:org_t)
- 2021-11-05
- 2021
- Engelska.
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Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 10:11
- Relaterad länk:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+ mobilizing agent and its inhibition proved to inhibit T-cell activation. However, the impact of the NAADP signaling on CD4+ T-cell differentiation and plasticity and on the inflammation in tissues other than the central nervous system remains unclear. In this study, we used an antagonist of NAADP signaling, trans-Ned 19, to study the role of NAADP in CD4+ T-cell differentiation and effector function. Partial blockade of NAADP signaling in naïve CD4+ T cells in vitro promoted the differentiation of Th17 cells. Interestingly, trans-Ned 19 also promoted the production of IL-10, co-expression of LAG-3 and CD49b and increased the suppressive capacity of Th17 cells. Moreover, using an IL-17A fate mapping mouse model, we showed that NAADP inhibition promotes conversion of Th17 cells into regulatory T cells in vitro and in vivo. In line with the results, we found that inhibiting NAADP ameliorates disease in a mouse model of intestinal inflammation. Thus, these results reveal a novel function of NAADP in controlling the differentiation and plasticity of CD4+ T cells.
Publikations- och innehållstyp
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- art (ämneskategori)
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Cells
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Till lärosätets databas
- Av författaren/redakt...
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Nawrocki, M
-
Lory, N
-
Bedke, T
-
Stumme, F
-
Diercks, BP
-
Guse, AH
-
visa fler...
-
Meier, C
-
Gagliani, N
-
Mittruecker, HW
-
Huber, S
-
visa färre...
- Artiklar i publikationen
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Cells
- Av lärosätet
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Karolinska Institutet