Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:148639309" > Epigenome-wide meta...
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000 | 16648naa a2201321 4500 | |
001 | oai:prod.swepub.kib.ki.se:148639309 | |
003 | SwePub | |
008 | 241009s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-466960 | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486393092 URI |
024 | 7 | a https://doi.org/10.1038/s41380-019-0605-z2 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4669602 URI |
040 | a (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jia, TYu Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China.;Fudan Univ, MOE Key Lab Computat Neurosci & Brain Inspired In, Shanghai, Peoples R China.4 aut |
245 | 1 0 | a Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group |
264 | c 2019-12-06 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Chu, CYu Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut |
700 | 1 | a Liu, Yu Fudan Univ, Zhongshan Hosp, Sch Basic Med Sci, Dept Biochem & Mol Biol,MOE Key Lab Metab & Mol M, Shanghai, Peoples R China.4 aut |
700 | 1 | a van Dongen, Ju Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.4 aut |
700 | 1 | a Papastergios, Eu Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut |
700 | 1 | a Armstrong, NJu Murdoch Univ, Math & Stat, Perth, WA, Australia.,Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.4 aut |
700 | 1 | a Bastin, MEu Univ Edinburgh MEB, Brain Res Imaging Ctr, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.;Univ Edinburgh MEB, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.4 aut |
700 | 1 | a Carrillo-Roa, Tu Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.4 aut |
700 | 1 | a den Braber, Au Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.4 aut |
700 | 1 | a Harris, Mu Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Edinburgh Imaging, Edinburgh, Midlothian, Scotland.4 aut |
700 | 1 | a Jansen, Ru Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.4 aut |
700 | 1 | a Liu, JYu Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA.4 aut |
700 | 1 | a Luciano, Mu Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland.,Queensland Univ Technol, Sch Clin Sci, Herston Imaging Res Facil, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Ori, APSu Univ Calif Los Angeles, UCLA Ctr Neurobehav Genet, Los Angeles, CA USA.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Prince Wales Hosp, Neuropsychiat Inst, Sydney, NSW, Australia.,Indiana Univ Sch Med, Radiol & Imaging Sci, Indianapolis, IN 46202 USA.4 aut |
700 | 1 | a Santianez, RRu Univ Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.;Ctr Invest Biomed Red Salud Mental, Santander, Spain.4 aut |
700 | 1 | a Ruggeri, Bu Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut |
700 | 1 | a Sarkisyan, Daniilu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)dansa302 |
700 | 1 | a Shin, Ju Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.4 aut |
700 | 1 | a Sungeun, Ku Indiana Univ Sch Med, Ctr Neuroimaging, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA.4 aut |
700 | 1 | a Gutierrez, DTu Univ Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.;Valdecilla Biomed Res Inst IDIVAL, Neuroimaging Unit, Technol Facil, Santander, Cantabria, Spain.4 aut |
700 | 1 | a van't Ent, Du Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.4 aut |
700 | 1 | a Ames, Du Natl Ageing Res Inst, Parkville, Vic, Australia.;Univ Melbourne, Acad Unit Psychiat Old Age, St Georges Hosp, Kew, Vic, Australia.4 aut |
700 | 1 | a Artiges, Eu Univ Paris 05, Inst Natl Sante & Rech Med, INSERM Unit 1000 Neuroimaging & Psychiat, Univ Paris Sud Paris Saclay, Orsay, France.;DIGITEO Labs, Gif Sur Yvette, France.;GH Nord Essonne Psychiat Dept 91G16, Orsay, France.4 aut |
700 | 1 | a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200 |
700 | 1 | a Banaschewski, Tu Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany.4 aut |
700 | 1 | a Bokde, ALWu Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland.;Trinity Coll Dublin, Trinity Inst Neurosci, Dublin, Ireland.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.4 aut |
700 | 1 | a Brodaty, Hu Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Univ New South Wales, Dementia Ctr Res Collaborat, Sch OfPsychiat, Sydney, NSW, Australia.4 aut |
700 | 1 | a Bromberg, Uu Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-3 Hamburg, Germany.4 aut |
700 | 1 | a Brouwer, Ru Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.4 aut |
700 | 1 | a Buchel, Cu Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-3 Hamburg, Germany.4 aut |
700 | 1 | a Quinlan, EBu Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut |
700 | 1 | a Cahn, Wu Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.4 aut |
700 | 1 | a de Zubicaray, GIu Queensland Univ Technol, Fac Hlth, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Ehrlich, Su Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany.4 aut |
700 | 1 | a Ekstrom, TJu Karolinska Institutet,Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.,Univ Calif Los Angeles, UCLA Ctr Neurobehav Genet, Los Angeles, CA USA.;Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Univ New South Wales, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia.4 aut |
700 | 1 | a Flor, Hu Heidelberg Univ, Med Fac Mannheim, CentralInst Mental Hlth, Dept Cognit & Clin Neurosci, Sq J5, Mannheim, Germany.;Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany.4 aut |
700 | 1 | a Frohner, JHu Tech Univ Dresden, Dept Psychiat, Dresden, Germany.;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany.,Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Neurosci Inst, Cape Town, South Africa.4 aut |
700 | 1 | a Frouin, Vu Univ Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France.4 aut |
700 | 1 | a Garavan, Hu Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.4 aut |
700 | 1 | a Gowland, Pu Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England.,Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.4 aut |
700 | 1 | a Heinz, Au Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, Berlin, Germany.4 aut |
700 | 1 | a Hoare, J4 aut |
700 | 1 | a Ittermann, Bu Phys Tech Bundesanstalt PTB, Berlin, Germany.,Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.4 aut |
700 | 1 | a Jahanshad, N4 aut |
700 | 1 | a Jiang, JY4 aut |
700 | 1 | a Kwok, JBu Univ Sydney, Cent Clin Sch, Brain & Mind Ctr, Camperdown, NSW 2050, Australia.;Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.4 aut |
700 | 1 | a Martin, NGu QIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Martinot, JLu Univ Paris 05, Inst Natl Sante & Rech Med, INSERM Unit 1000 Neuroimaging & Psychiat, Univ Paris Sud Paris Saclay, Orsay, France.;DIGITEO Labs, Gif Sur Yvette, France.;Cochin Hosp, Maison Solenn, Paris, France.4 aut |
700 | 1 | a Mather, KAu Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.4 aut |
700 | 1 | a McMahon, KL4 aut |
700 | 1 | a McRae, AFu Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Nees, Fu Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany.;Heidelberg Univ, Med Fac Mannheim, CentralInst Mental Hlth, Dept Cognit & Clin Neurosci, Sq J5, Mannheim, Germany.4 aut |
700 | 1 | a Orfanos, DPu Univ Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France.4 aut |
700 | 1 | a Paus, Tu Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil Hosp, Toronto, ON M6A 2E1, Canada.;Univ Toronto, Dept Psychol, Toronto, ON M6A 2E1, Canada.;Univ Toronto, Dept Psychiat, Toronto, ON M6A 2E1, Canada.,Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.4 aut |
700 | 1 | a Poustka, Lu Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany.4 aut |
700 | 1 | a Samann, PG4 aut |
700 | 1 | a Schofield, PRu Neurosci Res Australia, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sydney, NSW, Australia.4 aut |
700 | 1 | a Smolka, MNu Tech Univ Dresden, Dept Psychiat, Dresden, Germany.;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany.4 aut |
700 | 1 | a Stein, DJu Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Neurosci Inst, Cape Town, South Africa.;SAMRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa.4 aut |
700 | 1 | a Strike, LTu Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Teeuw, J4 aut |
700 | 1 | a Thalamuthu, Au Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.4 aut |
700 | 1 | a Trollor, J4 aut |
700 | 1 | a Walter, Hu Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, Berlin, Germany.4 aut |
700 | 1 | a Wardlaw, JMu Univ Edinburgh, Brain Res Imaging Ctr, Ctr Clin Brain Sci, Edinburgh Dementia Res Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland.4 aut |
700 | 1 | a Wen, W4 aut |
700 | 1 | a Whelan, Ru Trinity Coll Dublin, Sch Psychol, Dublin, Ireland.;Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland.4 aut |
700 | 1 | a Apostolova, LGu Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN 46202 USA.4 aut |
700 | 1 | a Binder, EBu Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.4 aut |
700 | 1 | a Boomsma, DI4 aut |
700 | 1 | a Calhoun, Vu Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA.;Emory Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA.4 aut |
700 | 1 | a Crespo-Facorro, Bu Univ Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.4 aut |
700 | 1 | a Deary, IJu Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland.4 aut |
700 | 1 | a Pol, HHu Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.4 aut |
700 | 1 | a Ophoff, RAu Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.;Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.4 aut |
700 | 1 | a Pausova, Zu Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.4 aut |
700 | 1 | a Sachdev, PS4 aut |
700 | 1 | a Saykin, A4 aut |
700 | 1 | a Wright, MJu QIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Thompson, PM4 aut |
700 | 1 | a Schumann, Gu Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut |
700 | 1 | a Desrivieres, Su Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 aut |
710 | 2 | a Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China.;Fudan Univ, MOE Key Lab Computat Neurosci & Brain Inspired In, Shanghai, Peoples R China.b Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.4 org |
773 | 0 | t Molecular psychiatryd : Springer Science and Business Media LLCg 26:8, s. 3884-3895q 26:8<3884-3895x 1476-5578x 1359-4184 |
856 | 4 | u https://www.nature.com/articles/s41380-019-0605-z.pdf |
856 | 4 | u https://doi.org/10.1038/s41380-019-0605-zy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1635001/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148639309 |
856 | 4 8 | u https://doi.org/10.1038/s41380-019-0605-z |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-466960 |
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