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FältnamnIndikatorerMetadata
00005372naa a2200973 4500
001oai:prod.swepub.kib.ki.se:148723237
003SwePub
008240701s2022 | |||||||||||000 ||eng|
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1487232372 URI
024a https://doi.org/10.1136/bmjopen-2020-0481662 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Hunter, KE4 aut
2451 0a Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity
264 c 2022-01-20
264 1b BMJ,c 2022
520 a Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups.Methods and analysisSystematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events.Ethics and disseminationApproved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases.PROSPERO registration numberCRD42020177408.
700a Johnson, BJ4 aut
700a Askie, L4 aut
700a Golley, RK4 aut
700a Baur, LA4 aut
700a Marschner, IC4 aut
700a Taylor, RW4 aut
700a Wolfenden, L4 aut
700a Wood, CT4 aut
700a Mihrshahi, S4 aut
700a Hayes, AJ4 aut
700a Rissel, C4 aut
700a Robledo, KP4 aut
700a O'Connor, DA4 aut
700a Espinoza, D4 aut
700a Staub, LP4 aut
700a Chadwick, P4 aut
700a Taki, S4 aut
700a Barba, A4 aut
700a Libesman, S4 aut
700a Aberoumand, M4 aut
700a Smith, WA4 aut
700a Sue-See, M4 aut
700a Hesketh, KD4 aut
700a Thomson, JL4 aut
700a Bryant, M4 aut
700a Paul, IM4 aut
700a Verbestel, V4 aut
700a Stough, CO4 aut
700a Wen, LM4 aut
700a Larsen, JK4 aut
700a O'Reilly, SL4 aut
700a Wasser, HM4 aut
700a Savage, JS4 aut
700a Ong, KK4 aut
700a Salvy, SJ4 aut
700a Messito, MJ4 aut
700a Gross, RS4 aut
700a Karssen, LT4 aut
700a Rasmussen, FE4 aut
700a Campbell, K4 aut
700a Linares, AM4 aut
700a Overby, NC4 aut
700a Palacios, C4 aut
700a Joshipura, KJ4 aut
700a Acero, CG4 aut
700a Lakshman, R4 aut
700a Thompson, AL4 aut
700a Maffeis, C4 aut
700a Oken, E4 aut
700a Ghaderi, Au Karolinska Institutet4 aut
700a Rivera, MC4 aut
700a Perez-Exposito, AB4 aut
700a Banna, JC4 aut
700a de la Haye, K4 aut
700a Goran, M4 aut
700a Roed, M4 aut
700a Anzman-Frasca, S4 aut
700a Taylor, BJ4 aut
700a Seidler, AL4 aut
710a Karolinska Institutet4 org
773t BMJ opend : BMJg 12:1, s. e048166-q 12:1<e048166-x 2044-6055
856u https://bmjopen.bmj.com/content/bmjopen/12/1/e048166.full.pdf
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148723237
8564 8u https://doi.org/10.1136/bmjopen-2020-048166

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