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Wnt/beta-catenin si...
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
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Wang, Y (författare)
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Zheng, LX (författare)
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Shang, WJ (författare)
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visa fler...
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Yang, ZC (författare)
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Li, TY (författare)
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Liu, F (författare)
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Shao, W (författare)
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Lv, L (författare)
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Chai, L (författare)
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Qu, LX (författare)
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Xu, Q (författare)
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Du, J (författare)
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- Liang, XM (författare)
- Karolinska Institutet
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Zeng, JP (författare)
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Jia, JH (författare)
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(creator_code:org_t)
- 2022-05-09
- 2022
- Engelska.
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Ingår i: Cell death and differentiation. - : Springer Science and Business Media LLC. - 1476-5403 .- 1350-9047. ; 29:11, s. 2190-2202
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance. Ferroptosis is a form of regulated cell death, induced by an iron-dependent accumulation of lipid peroxides during chemotherapy. However, whether the Wnt/beta-catenin signaling directly controls resistance to cell death, remains unclear. Here, we show that the activation of the Wnt/beta-catenin signaling attenuates cellular lipid ROS production and subsequently inhibits ferroptosis in GC cells. The beta-catenin/TCF4 transcription complex directly binds to the promoter region of GPX4 and induces its expression, resulting in the suppression of ferroptotic cell death. Concordantly, TCF4 deficiency promotes cisplatin-induced ferroptosis in vitro and in vivo. Thus, we demonstrate that the aberrant activation of the Wnt/beta-catenin signaling confers ferroptosis resistance and suggests a potential therapeutic strategy to enhance chemo-sensitivity for advanced GC patients.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wang, Y
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Zheng, LX
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Shang, WJ
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Yang, ZC
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Li, TY
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Liu, F
-
visa fler...
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Shao, W
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Lv, L
-
Chai, L
-
Qu, LX
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Xu, Q
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Du, J
-
Liang, XM
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Zeng, JP
-
Jia, JH
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visa färre...
- Artiklar i publikationen
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Cell death and d ...
- Av lärosätet
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Karolinska Institutet