Subtype-Specific Surface Proteins on Adipose Tissue Macrophages and Their Association to Obesity-Induced Insulin Resistance

Strand, K (författare)

Stiglund, N (författare)

Haugstoyl, ME (författare)

Kamyab, Z (författare)

Langhelle, V (författare)

Dyer, L (författare)

Busch, C (författare)

Cornillet, M (författare)

Hjellestad, ID (författare)

Nielsen, HJ (författare)

Njolstad, PR (författare)

Mellgren, G (författare)

Ferno, J (författare)

(creator_code:org_t)

2022-04-11
2022
Engelska.
Ingår i: Frontiers in endocrinology. - : Frontiers Media SA. - 1664-2392. ; 13, s. 856530-

Relaterad länk:: http://kipublication...; visa fler...; https://doi.org/10.3...; visa färre...

Abstract Ämnesord

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A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis of metabolic diseases, but a detailed characterization of pro- and anti-inflammatory adipose tissue macrophages (ATMs) in human obesity and how they are distributed in visceral- and subcutaneous adipose depots is lacking. In this study, we performed a surface proteome screening of pro- and anti-inflammatory ATMs in both subcutaneous- (SAT) and visceral adipose tissue (VAT) and evaluated their relationship with systemic insulin resistance. From the proteomics screen we found novel surface proteins specific to M1-like- and M2-like macrophages, and we identified depot-specific immunophenotypes in SAT and VAT. Furthermore, we found that insulin resistance, assessed by HOMA-IR, was positively associated with a relative increase in pro-inflammatory M1-like macrophages in both SAT and VAT.

Av författaren/redakt...: Strand, K; Stiglund, N; Haugstoyl, ME; Kamyab, Z; Langhelle, V; Dyer, L; visa fler...; Busch, C; Cornillet, M; Hjellestad, ID; Nielsen, HJ; Njolstad, PR; Mellgren, G; Bjorkstrom, NK; Ferno, J; visa färre...

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