Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:149527611" >
Oxime derivative TF...
Oxime derivative TFOBO promotes cell death by modulating reactive oxygen species and regulating NADPH oxidase activity in myeloid leukemia
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
2022-05-07
-
Springer Science and Business Media LLC,2022
Nummerbeteckningar
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:149527611
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:149527611URI
-
https://doi.org/10.1038/s41598-022-11543-8DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Several derivatives derived from the oxime structure have been reported as potential anticancer agents in various cancers. Here, we first tested a novel oxime-containing derivative of 2-((2,4,5-trifluorobenzyl)oxy)benzaldehyde oxime (TFOBO) to evaluate its anticancer effect in myeloid leukemic cells. Compared to (2-((2,4,5-trifluorobenzyl)oxy)phenyl)methanol (TFOPM), the oxime derivative TFOBO suppresses leukemic cell growth by significantly increasing reactive oxygen species (ROS) levels and cell death. Leukemic cells treated with TFOBO displayed apoptotic cell death, as indicated by nuclear condensation, DNA fragmentation, and annexin V staining. TFOBO increases Bax/Bcl2 levels, caspase9, and caspase3/7 activity and decreases mitochondrial membrane potential. ROS production was reduced by N-acetyl-l-cysteine, a ROS scavenger, diphenyleneiodonium chloride, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, after exogenous TFOBO treatment. ROS inhibitors protect leukemic cells from TFOBO-induced cell death. Thus, our study findings suggest that TFOBO promotes apoptosis by modulating ROS and regulating NADPH oxidase activity. Collectively, the oxime-containing derivative TFOBO is a novel therapeutic drug for myeloid leukemia.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Kwak, JH
(författare)
-
Woo, SY
(författare)
-
Kim, BY
(författare)
-
Son, Y
(författare)
-
Choi, HS
(författare)
-
Kim, J
(författare)
-
Kwon, M
(författare)
-
Cho, HR
(författare)
-
Eo, SK
(författare)
-
Nam, JH
(författare)
-
Kim, HS
(författare)
-
Baryawno, NKarolinska Institutet
(författare)
-
Lee, D
(författare)
-
Kim, K
(författare)
-
Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Scientific reports: Springer Science and Business Media LLC12:1, s. 7519-2045-2322
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jo, A
-
Kwak, JH
-
Woo, SY
-
Kim, BY
-
Son, Y
-
Choi, HS
-
visa fler...
-
Kim, J
-
Kwon, M
-
Cho, HR
-
Eo, SK
-
Nam, JH
-
Kim, HS
-
Baryawno, N
-
Lee, D
-
Kim, K
-
visa färre...
- Artiklar i publikationen
-
Scientific repor ...
- Av lärosätet
-
Karolinska Institutet