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Mobilization of sys...
Mobilization of systemic CCL4 following HIV pre-exposure prophylaxis in young men in Africa
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Petkov, S (författare)
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Herrera, C (författare)
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Else, L (författare)
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Mugaba, S (författare)
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Namubiru, P (författare)
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Odoch, G (författare)
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Opoka, D (författare)
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Pillay, ADAP (författare)
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Seiphetlo, TB (författare)
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Serwanga, J (författare)
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Ssemata, AS (författare)
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Kaleebu, P (författare)
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Webb, EL (författare)
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Khoo, S (författare)
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Lebina, L (författare)
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Gray, CM (författare)
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Martinson, N (författare)
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Fox, J (författare)
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- Chiodi, F (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-07-27
- 2022
- Engelska.
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Ingår i: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 13, s. 965214-
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- HIV-1 pre-exposure prophylaxis (PrEP) relies on inhibition of HIV-1 replication steps. To understand how PrEP modulates the immunological environment, we derived the plasma proteomic profile of men receiving emtricitabine-tenofovir (FTC-TDF) or emtricitabine-tenofovir alafenamide (FTC-TAF) during the CHAPS trial in South Africa and Uganda (NCT03986970). The CHAPS trial randomized 144 participants to one control and 8 PrEP arms, differing by drug type, number of PrEP doses and timing from final PrEP dose to sampling. Blood was collected pre- and post-PrEP. The inflammatory profile of plasma samples was analyzed using Olink (N=92 proteins) and Luminex (N=33) and associated with plasma drug concentrations using mass spectrometry. The proteins whose levels changed most significantly from pre- to post-PrEP were CCL4, CCL3 and TNF-α; CCL4 was the key discriminator between pre- and post-PrEP samples. CCL4 and CCL3 levels were significantly increased in post-PrEP samples compared to control specimens. CCL4 was significantly correlated with FTC drug levels in plasma. Production of inflammatory chemokines CCL4 and CCL3 in response to short-term PrEP indicates the mobilization of ligands which potentially block virus attachment to CCR5 HIV-1 co-receptor. The significant correlation between CCL4 and FTC levels suggests that CCL4 increase is modulated as an inflammatory response to PrEP.
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Petkov, S
-
Herrera, C
-
Else, L
-
Mugaba, S
-
Namubiru, P
-
Odoch, G
-
visa fler...
-
Opoka, D
-
Pillay, ADAP
-
Seiphetlo, TB
-
Serwanga, J
-
Ssemata, AS
-
Kaleebu, P
-
Webb, EL
-
Khoo, S
-
Lebina, L
-
Gray, CM
-
Martinson, N
-
Fox, J
-
Chiodi, F
-
visa färre...
- Artiklar i publikationen
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Frontiers in imm ...
- Av lärosätet
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Karolinska Institutet