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- Ashenafi, SKarolinska Institutet (författare)
Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB)
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
- 2022-08-12
- MDPI AG,2022
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:150599416
- http://kipublications.ki.se/Default.aspx?queryparsed=id:150599416URI
- https://doi.org/10.3390/nu14163318DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- A typical trait of chronic tuberculosis (TB) is substantial weight loss that concurs with a drop in blood hemoglobin (Hb) levels, causing anemia. In this observational study, we explored Hb levels in 345 pulmonary TB patients. They were divided into anemic or non-anemic groups which related to clinical symptoms, anthropometric measurements, and immune status. Data was obtained in a randomized controlled trial that we previously conducted using nutritional supplementation of TB patients in Ethiopia. A post hoc analysis demonstrated that anemic patients have a higher composite clinical TB score at baseline than non-anemic patients. Consequently, Hb values were significantly lower in underweight patients with moderate to severe disease and/or cavitary TB compared to normal weight patients with mild disease or non-cavitary TB. Anemia was associated with a low body mass index (BMI), low mid-upper arm circumference (MUAC), lower peripheral CD4 and CD8 T cells counts and IFN-γ levels, and a higher erythrocyte sedimentation rate (ESR). Chronic inflammation and TB disease progression appeared to be driven by elevated systemic levels of pro-inflammatory IL-6 in anemic patients. Multivariable modeling confirmed that a low Hb and a low BMI were key variables related to an unfavorable TB disease status. Although Hb levels increased with successful chemotherapy, anemic TB patients maintained a slower clinical recovery compared to non-anemic patients during the intensive phase treatment (two months). In conclusion, anemia is a strong predictor of wasting, disease severity, inflammation, and slower recovery in patients with pulmonary TB.
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Bekele, A (författare)
- Aseffa, G (författare)
- Amogne, W (författare)
- Kassa, E (författare)
- Aderaye, G (författare)
- Worku, A (författare)
- Bergman, PKarolinska Institutet (författare)
- Brighenti, SKarolinska Institutet (författare)
- Karolinska Institutet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Nutrients: MDPI AG14:162072-6643
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- Bekele, A
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- Worku, A
- Bergman, P
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