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Meta-Analysis and V...
Meta-Analysis and Validation of a Colorectal Cancer Risk Prediction Model Using Deep Sequenced Fecal Metagenomes
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Obon-Santacana, M (författare)
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Mas-Lloret, J (författare)
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Bars-Cortina, D (författare)
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Criado-Mesas, L (författare)
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Carreras-Torres, R (författare)
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Diez-Villanueva, A (författare)
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Moratalla-Navarro, F (författare)
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Guino, E (författare)
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Ibanez-Sanz, G (författare)
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Rodriguez-Alonso, L (författare)
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Mulet-Margalef, N (författare)
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Mata, A (författare)
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Garcia-Rodriguez, A (författare)
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Duell, EJ (författare)
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- Pimenoff, VN (författare)
- Karolinska Institutet
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Moreno, V (författare)
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(creator_code:org_t)
- 2022-08-30
- 2022
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:17
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- The gut microbiome is a potential modifiable risk factor for colorectal cancer (CRC). We re-analyzed all eight previously published stool sequencing data and conducted an MWAS meta-analysis. We used cross-validated LASSO predictive models to identify a microbiome signature for predicting the risk of CRC and precancerous lesions. These models were validated in a new study, Colorectal Cancer Screening (COLSCREEN), including 156 participants that were recruited in a CRC screening context. The MWAS meta-analysis identified 95 bacterial species that were statistically significantly associated with CRC (FDR < 0.05). The LASSO CRC predictive model obtained an area under the receiver operating characteristic curve (aROC) of 0.81 (95%CI: 0.78–0.83) and the validation in the COLSCREEN dataset was 0.75 (95%CI: 0.66–0.84). This model selected a total of 32 species. The aROC of this CRC-trained model to predict precancerous lesions was 0.52 (95%CI: 0.41–0.63). We have identified a signature of 32 bacterial species that have a good predictive accuracy to identify CRC but not precancerous lesions, suggesting that the identified microbes that were enriched or depleted in CRC are merely a consequence of the tumor. Further studies should focus on CRC as well as precancerous lesions with the intent to implement a microbiome signature in CRC screening programs.
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Cancers
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Obon-Santacana, ...
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Mas-Lloret, J
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Bars-Cortina, D
-
Criado-Mesas, L
-
Carreras-Torres, ...
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Diez-Villanueva, ...
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visa fler...
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Moratalla-Navarr ...
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Guino, E
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Ibanez-Sanz, G
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Rodriguez-Alonso ...
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Mulet-Margalef, ...
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Mata, A
-
Garcia-Rodriguez ...
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Duell, EJ
-
Pimenoff, VN
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Moreno, V
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visa färre...
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Karolinska Institutet