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Allergen provocatio...
Allergen provocation tests in respiratory research: building on 50 years of experience
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- Gauvreau, GM (författare)
- McMaster University
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- Davis, BE (författare)
- University of Saskatchewan
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- Scadding, G (författare)
- Imperial College London
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- Boulet, LP (författare)
- Laval University
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- Bjermer, Leif (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Respiratory Medicine,Lund University Research Groups
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- Chaker, A (författare)
- Technical University of Munich,Klinikum rechts der Isar
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- Cockcroft, DW (författare)
- University of Saskatchewan
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- Dahlen, B (författare)
- Karolinska Institute,Karolinska Institutet
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- Fokkens, W (författare)
- Technical University of Munich,Klinikum rechts der Isar
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- Hellings, P (författare)
- University of Amsterdam
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- Lazarinis, N (författare)
- Karolinska Institute,Karolinska Institutet
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- O'Byrne, PM (författare)
- McMaster University
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- Tufvesson, Ellen (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Tornbladinstitutet,Lungfysiologi och biomarkörer,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Tornblad Institute,Lung physiology and biomarkers
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- Quirce, S (författare)
- University Hospital La Paz
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- Van Maaren, M (författare)
- Erasmus University Medical Center
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- de Jongh, FH (författare)
- University of Twente
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- Diamant, Zuzana (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Catholic University of Leuven,University Medical Center Groningen,Skåne University Hospital
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(creator_code:org_t)
- 2022-01-27
- 2022
- Engelska.
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 60:2
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://kipublication...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The allergen provocation test is an established model of allergic airway diseases, including asthma and allergic rhinitis, allowing the study of allergen-induced changes in respiratory physiology and inflammatory mechanisms in sensitised individuals as well as their associations. In the upper airways, allergen challenge is focused on the clinical and pathophysiological sequelae of the early allergic response, and is applied both as a diagnostic tool and in research settings. In contrast, bronchial allergen challenge has almost exclusively served as a research tool in specialised research settings with a focus on the late asthmatic response and the underlying type 2 inflammation. The allergen-induced late asthmatic response is also characterised by prolonged airway narrowing, increased nonspecific airway hyperresponsiveness and features of airway remodelling including the small airways, and hence allows the study of several key mechanisms and features of asthma. In line with these characteristics, allergen challenge has served as a valued tool to study the cross-talk of the upper and lower airways and in proof-of-mechanism studies of drug development. In recent years, several new insights into respiratory phenotypes and endotypes including the involvement of the upper and small airways, innovative biomarker sampling methods and detection techniques, refined lung function testing as well as targeted treatment options further shaped the applicability of the allergen provocation test in precision medicine. These topics, along with descriptions of subject populations and safety, in line with the updated Global Initiative for Asthma 2021 document, will be addressed in this review.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gauvreau, GM
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Davis, BE
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Scadding, G
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Boulet, LP
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Bjermer, Leif
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Chaker, A
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visa fler...
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Cockcroft, DW
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Dahlen, B
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Fokkens, W
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Hellings, P
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Lazarinis, N
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O'Byrne, PM
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Tufvesson, Ellen
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Quirce, S
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Van Maaren, M
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de Jongh, FH
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Diamant, Zuzana
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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The European res ...
- Av lärosätet
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Karolinska Institutet
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Lunds universitet