Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:151780112" >
Metabolomics and a ...
Metabolomics and a Breath Sensor Identify Acetone as a Biomarker for Heart Failure
-
Gladding, PA (författare)
-
Cooper, M (författare)
-
Young, R (författare)
-
visa fler...
-
Loader, S (författare)
-
Smith, K (författare)
-
Zarate, E (författare)
-
Green, S (författare)
-
Boas, SGV (författare)
-
Shepherd, P (författare)
-
Kakadiya, P (författare)
-
Thorstensen, E (författare)
-
Keven, C (författare)
-
Coe, M (författare)
-
Jullig, M (författare)
-
Zhang, E (författare)
-
- Schlegel, TT (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2022-12-21
- 2023
- Engelska.
-
Ingår i: Biomolecules. - : MDPI AG. - 2218-273X. ; 13:1
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Multi-omics delivers more biological insight than targeted investigations. We applied multi-omics to patients with heart failure with reduced ejection fraction (HFrEF). Methods: 46 patients with HFrEF and 20 controls underwent metabolomic profiling, including liquid/gas chromatography mass spectrometry (LC-MS/GC-MS) and solid-phase microextraction (SPME) volatilomics in plasma and urine. HFrEF was defined using left ventricular global longitudinal strain, ejection fraction and NTproBNP. A consumer breath acetone (BrACE) sensor validated results in n = 73. Results: 28 metabolites were identified by GCMS, 35 by LCMS and 4 volatiles by SPME in plasma and urine. Alanine, aspartate and glutamate, citric acid cycle, arginine biosynthesis, glyoxylate and dicarboxylate metabolism were altered in HFrEF. Plasma acetone correlated with NT-proBNP (r = 0.59, 95% CI 0.4 to 0.7), 2-oxovaleric and cis-aconitic acid, involved with ketone metabolism and mitochondrial energetics. BrACE > 1.5 ppm discriminated HF from other cardiac pathology (AUC 0.8, 95% CI 0.61 to 0.92, p < 0.0001). Conclusion: Breath acetone discriminated HFrEF from other cardiac pathology using a consumer sensor, but was not cardiac specific.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gladding, PA
-
Cooper, M
-
Young, R
-
Loader, S
-
Smith, K
-
Zarate, E
-
visa fler...
-
Green, S
-
Boas, SGV
-
Shepherd, P
-
Kakadiya, P
-
Thorstensen, E
-
Keven, C
-
Coe, M
-
Jullig, M
-
Zhang, E
-
Schlegel, TT
-
visa färre...
- Artiklar i publikationen
-
Biomolecules
- Av lärosätet
-
Karolinska Institutet