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Non-occupational ph...
Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies
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Garcia, L (författare)
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Pearce, M (författare)
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Abbas, A (författare)
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visa fler...
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Mok, A (författare)
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Strain, T (författare)
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Ali, S (författare)
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- Crippa, A (författare)
- Karolinska Institutet
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Dempsey, PC (författare)
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Golubic, R (författare)
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Kelly, P (författare)
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Laird, Y (författare)
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McNamara, E (författare)
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Moore, S (författare)
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de Sa, TH (författare)
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Smith, AD (författare)
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Wijndaele, K (författare)
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Woodcock, J (författare)
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Brage, S (författare)
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visa färre...
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(creator_code:org_t)
- 2023-02-28
- 2023
- Engelska.
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Ingår i: British journal of sports medicine. - : BMJ. - 1473-0480 .- 0306-3674. ; 57:15, s. 979-
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population.DesignSystematic review and cohort-level dose-response meta-analysis.Data sourcesPubMed, Scopus, Web of Science and reference lists of published studies.Eligibility criteriaProspective cohort studies with (1) general population samples >10 000 adults, (2) ≥3 physical activity categories, and (3) risk measures and CIs for all-cause mortality or incident total cardiovascular disease, coronary heart disease, stroke, heart failure, total cancer and site-specific cancers (head and neck, myeloid leukaemia, myeloma, gastric cardia, lung, liver, endometrium, colon, breast, bladder, rectum, oesophagus, prostate, kidney).Results196 articles were included, covering 94 cohorts with >30 million participants. The evidence base was largest for all-cause mortality (50 separate results; 163 415 543 person-years, 811 616 events), and incidence of cardiovascular disease (37 results; 28 884 209 person-years, 74 757 events) and cancer (31 results; 35 500 867 person-years, 185 870 events). In general, higher activity levels were associated with lower risk of all outcomes. Differences in risk were greater between 0 and 8.75 marginal metabolic equivalent of task-hours per week (mMET-hours/week) (equivalent to the recommended 150 min/week of moderate-to-vigorous aerobic physical activity), with smaller marginal differences in risk above this level to 17.5 mMET-hours/week, beyond which additional differences were small and uncertain. Associations were stronger for all-cause (relative risk (RR) at 8.75 mMET-hours/week: 0.69, 95% CI 0.65 to 0.73) and cardiovascular disease (RR at 8.75 mMET-hours/week: 0.71, 95% CI 0.66 to 0.77) mortality than for cancer mortality (RR at 8.75 mMET-hours/week: 0.85, 95% CI 0.81 to 0.89). If all insufficiently active individuals had achieved 8.75 mMET-hours/week, 15.7% (95% CI 13.1 to 18.2) of all premature deaths would have been averted.ConclusionsInverse non-linear dose–response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults.PROSPERO registration numberCRD42018095481.
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- Av författaren/redakt...
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Garcia, L
-
Pearce, M
-
Abbas, A
-
Mok, A
-
Strain, T
-
Ali, S
-
visa fler...
-
Crippa, A
-
Dempsey, PC
-
Golubic, R
-
Kelly, P
-
Laird, Y
-
McNamara, E
-
Moore, S
-
de Sa, TH
-
Smith, AD
-
Wijndaele, K
-
Woodcock, J
-
Brage, S
-
visa färre...
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British journal ...
- Av lärosätet
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Karolinska Institutet