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Non-occupational ph...
Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:152068882
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152068882URI
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https://doi.org/10.1136/bjsports-2022-105669DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population.DesignSystematic review and cohort-level dose-response meta-analysis.Data sourcesPubMed, Scopus, Web of Science and reference lists of published studies.Eligibility criteriaProspective cohort studies with (1) general population samples >10 000 adults, (2) ≥3 physical activity categories, and (3) risk measures and CIs for all-cause mortality or incident total cardiovascular disease, coronary heart disease, stroke, heart failure, total cancer and site-specific cancers (head and neck, myeloid leukaemia, myeloma, gastric cardia, lung, liver, endometrium, colon, breast, bladder, rectum, oesophagus, prostate, kidney).Results196 articles were included, covering 94 cohorts with >30 million participants. The evidence base was largest for all-cause mortality (50 separate results; 163 415 543 person-years, 811 616 events), and incidence of cardiovascular disease (37 results; 28 884 209 person-years, 74 757 events) and cancer (31 results; 35 500 867 person-years, 185 870 events). In general, higher activity levels were associated with lower risk of all outcomes. Differences in risk were greater between 0 and 8.75 marginal metabolic equivalent of task-hours per week (mMET-hours/week) (equivalent to the recommended 150 min/week of moderate-to-vigorous aerobic physical activity), with smaller marginal differences in risk above this level to 17.5 mMET-hours/week, beyond which additional differences were small and uncertain. Associations were stronger for all-cause (relative risk (RR) at 8.75 mMET-hours/week: 0.69, 95% CI 0.65 to 0.73) and cardiovascular disease (RR at 8.75 mMET-hours/week: 0.71, 95% CI 0.66 to 0.77) mortality than for cancer mortality (RR at 8.75 mMET-hours/week: 0.85, 95% CI 0.81 to 0.89). If all insufficiently active individuals had achieved 8.75 mMET-hours/week, 15.7% (95% CI 13.1 to 18.2) of all premature deaths would have been averted.ConclusionsInverse non-linear dose–response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults.PROSPERO registration numberCRD42018095481.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pearce, M
(författare)
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Abbas, A
(författare)
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Mok, A
(författare)
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Strain, T
(författare)
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Ali, S
(författare)
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Crippa, AKarolinska Institutet
(författare)
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Dempsey, PC
(författare)
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Golubic, R
(författare)
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Kelly, P
(författare)
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Laird, Y
(författare)
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McNamara, E
(författare)
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Moore, S
(författare)
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de Sa, TH
(författare)
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Smith, AD
(författare)
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Wijndaele, K
(författare)
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Woodcock, J
(författare)
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Brage, S
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British journal of sports medicine: BMJ57:15, s. 979-+1473-04800306-3674
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Garcia, L
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Pearce, M
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Abbas, A
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Mok, A
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Strain, T
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Ali, S
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visa fler...
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Crippa, A
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Dempsey, PC
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Golubic, R
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Kelly, P
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Laird, Y
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McNamara, E
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Moore, S
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de Sa, TH
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Smith, AD
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Wijndaele, K
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Woodcock, J
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Brage, S
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visa färre...
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Karolinska Institutet