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Impact of Sociodemo...
Impact of Sociodemographic, Premorbid, and Injury-Related Factors on Patient-Reported Outcome Trajectories after Traumatic Brain Injury (TBI)
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von Steinbuechel, N (författare)
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Hahm, S (författare)
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Muehlan, H (författare)
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visa fler...
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Arango-Lasprilla, JC (författare)
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Bockhop, F (författare)
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Covic, A (författare)
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Schmidt, S (författare)
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Steyerberg, EW (författare)
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Maas, AIR (författare)
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Menon, D (författare)
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Andelic, N (författare)
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Zeldovich, M (författare)
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, TR TBI Participants Investigators (författare)
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visa färre...
- 2023-03-14
- 2023
- Engelska.
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Ingår i: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 12:6
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- Traumatic brain injury (TBI) remains one of the leading causes of death and disability worldwide. To better understand its impact on various outcome domains, this study pursues the following: (1) longitudinal outcome assessments at three, six, and twelve months post-injury; (2) an evaluation of sociodemographic, premorbid, and injury-related factors, and functional recovery contributing to worsening or improving outcomes after TBI. Using patient-reported outcome measures, recuperation trends after TBI were identified by applying Multivariate Latent Class Mixed Models (MLCMM). Instruments were grouped into TBI-specific and generic health-related quality of life (HRQoL; QOLIBRI-OS, SF-12v2), and psychological and post-concussion symptoms (GAD-7, PHQ-9, PCL-5, RPQ). Multinomial logistic regressions were carried out to identify contributing factors. For both outcome sets, the four-class solution provided the best match between goodness of fit indices and meaningful clinical interpretability. Both models revealed similar trajectory classes: stable good health status (HRQoL: n = 1944; symptoms: n = 1963), persistent health impairments (HRQoL: n = 442; symptoms: n = 179), improving health status (HRQoL: n = 83; symptoms: n = 243), and deteriorating health status (HRQoL: n = 86; symptoms: n = 170). Compared to individuals with stable good health status, the other groups were more likely to have a lower functional recovery status at three months after TBI (i.e., the GOSE), psychological problems, and a lower educational attainment. Outcome trajectories after TBI show clearly distinguishable patterns which are reproducible across different measures. Individuals characterized by persistent health impairments and deterioration require special attention and long-term clinical monitoring and therapy.
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Till lärosätets databas
- Av författaren/redakt...
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von Steinbuechel ...
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Hahm, S
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Muehlan, H
-
Arango-Lasprilla ...
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Bockhop, F
-
Covic, A
-
visa fler...
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Schmidt, S
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Steyerberg, EW
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Maas, AIR
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Menon, D
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Andelic, N
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Zeldovich, M
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, TR TBI Partici ...
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visa färre...
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Journal of clini ...
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Karolinska Institutet