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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03225naa a2200481 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:152293832 | |
| 003 | SwePub | |
| 008 | 240701s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1522938322 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-023-36002-42 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brown, BP4 aut |
| 245 | 1 0 | a Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial |
| 264 | c 2023-01-30 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2023 |
| 520 | a Effective contraceptives are a global health imperative for reproductive-aged women. However, there remains a lack of rigorous data regarding the effects of contraceptive options on vaginal bacteria and inflammation. Among 218 women enrolled into a substudy of the ECHO Trial (NCT02550067), we evaluate the effect of injectable intramuscular depot medroxyprogesterone acetate (DMPA-IM), levonorgestrel implant (LNG), and a copper intrauterine device (Cu-IUD) on the vaginal environment after one and six consecutive months of use, using 16S rRNA gene sequencing and multiplex cytokine assays. Primary endpoints include incident BV occurrence, bacterial diversity, and bacterial and cytokine concentrations. Secondary endpoints are bacterial and cytokine concentrations associated with later HIV seroconversion. Participants randomized to Cu-IUD exhibit elevated bacterial diversity, increased cytokine concentrations, and decreased relative abundance of lactobacilli after one and six months of use, relative to enrollment and other contraceptive options. Total bacterial loads of women using Cu-IUD increase 5.5 fold after six months, predominantly driven by increases in the concentrations of several inflammatory anaerobes. Furthermore, growth of L. crispatus (MV-1A-US) is inhibited by Cu2+ ions below biologically relevant concentrations, in vitro. Our work illustrates deleterious effects on the vaginal environment induced by Cu-IUD initiation, which may adversely impact sexual and reproductive health. | |
| 700 | 1 | a Feng, C4 aut |
| 700 | 1 | a Tanko, RF4 aut |
| 700 | 1 | a Jaumdally, SZ4 aut |
| 700 | 1 | a Bunjun, R4 aut |
| 700 | 1 | a Dabee, S4 aut |
| 700 | 1 | a Happel, AU4 aut |
| 700 | 1 | a Gasper, M4 aut |
| 700 | 1 | a Nyangahu, DD4 aut |
| 700 | 1 | a Onono, M4 aut |
| 700 | 1 | a Nair, G4 aut |
| 700 | 1 | a Palanee-Phillips, T4 aut |
| 700 | 1 | a Scoville, CW4 aut |
| 700 | 1 | a Heller, K4 aut |
| 700 | 1 | a Baeten, JM4 aut |
| 700 | 1 | a Bosinger, SE4 aut |
| 700 | 1 | a Burgener, Au Karolinska Institutet4 aut |
| 700 | 1 | a Passmore, JAS4 aut |
| 700 | 1 | a Heffron, R4 aut |
| 700 | 1 | a Jaspan, HB4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 14:1, s. 499-q 14:1<499-x 2041-1723 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152293832 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-023-36002-4 |
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