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Structural analysis...
Structural analysis and molecular dynamics simulation studies of HIV-1 antisense protein predict its potential role in HIV replication and pathogenesis
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Sathiyamani, B (författare)
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Daniel, EA (författare)
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Ansar, S (författare)
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Esakialraj, BH (författare)
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Hassan, S (författare)
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Revanasiddappa, PD (författare)
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Keshavamurthy, A (författare)
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Roy, S (författare)
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Vetrivel, U (författare)
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Hanna, LE (författare)
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- 2023-03-20
- 2023
- Engelska.
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Ingår i: Frontiers in microbiology. - : Frontiers Media SA. - 1664-302X. ; 14, s. 1152206-
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- The functional significance of the HIV-1 Antisense Protein (ASP) has been a paradox since its discovery. The expression of this protein in HIV-1-infected cells and its involvement in autophagy, transcriptional regulation, and viral latency have sporadically been reported in various studies. Yet, the definite role of this protein in HIV-1 infection remains unclear. Deciphering the 3D structure of HIV-1 ASP would throw light on its potential role in HIV lifecycle and host-virus interaction. Hence, using extensive molecular modeling and dynamics simulation for 200 ns, we predicted the plausible 3D-structures of ASP from two reference strains of HIV-1 namely, Indie-C1 (subtype-C) and NL4-3 (subtype-B) so as to derive its functional implication through structural domain analysis. In spite of sequence and structural differences in subtype B and C ASP, both structures appear to share common domains like the Von Willebrand Factor Domain-A (VWFA), Integrin subunit alpha-X (ITGSX), and ETV6-Transcriptional repressor, thereby reiterating the potential role of HIV-1 ASP in transcriptional repression and autophagy, as reported in earlier studies. Gromos-based cluster analysis of the centroid structures also reassured the accuracy of the prediction. This is the first study to elucidate a highly plausible structure for HIV-1 ASP which could serve as a feeder for further experimental validation studies.
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Sathiyamani, B
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Daniel, EA
-
Ansar, S
-
Esakialraj, BH
-
Hassan, S
-
Revanasiddappa, ...
-
visa fler...
-
Keshavamurthy, A
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Roy, S
-
Vetrivel, U
-
Hanna, LE
-
visa färre...
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Frontiers in mic ...
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Karolinska Institutet