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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05674naa a2201357 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:153250547 | |
| 003 | SwePub | |
| 008 | 240701s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1532505472 URI |
| 024 | 7 | a https://doi.org/10.3324/haematol.2022.2808472 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Marchesi, F4 aut |
| 245 | 1 0 | a COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA) |
| 264 | c 2022-05-12 | |
| 264 | 1 | b Ferrata Storti Foundation (Haematologica),c 2023 |
| 520 | a Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible. | |
| 700 | 1 | a Salmanton-Garcia, J4 aut |
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| 700 | 1 | a Piukovics, K4 aut |
| 700 | 1 | a Nucci, M4 aut |
| 700 | 1 | a Lopez-Garcia, A4 aut |
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| 700 | 1 | a Cabirta, A4 aut |
| 700 | 1 | a Ormazabal-Velez, I4 aut |
| 700 | 1 | a Jaksic, O4 aut |
| 700 | 1 | a Buquicchio, C4 aut |
| 700 | 1 | a Bonuomo, V4 aut |
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| 700 | 1 | a Lamure, S4 aut |
| 700 | 1 | a Finizio, O4 aut |
| 700 | 1 | a Fernandez, N4 aut |
| 700 | 1 | a Falces-Romero, I4 aut |
| 700 | 1 | a Blennow, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Bergantim, R4 aut |
| 700 | 1 | a Ali, N4 aut |
| 700 | 1 | a Win, S4 aut |
| 700 | 1 | a Van Praet, J4 aut |
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| 700 | 1 | a Ammatuna, E4 aut |
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| 700 | 1 | a Cornely, OA4 aut |
| 700 | 1 | a Pagano, L4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Haematologicad : Ferrata Storti Foundation (Haematologica)g 108:1, s. 22-33q 108:1<22-33x 1592-8721x 0390-6078 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153250547 |
| 856 | 4 8 | u https://doi.org/10.3324/haematol.2022.280847 |
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- Marchesi, F
- Salmanton-Garcia ...
- Emarah, Z
- Piukovics, K
- Nucci, M
- Lopez-Garcia, A
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- Racil, Z
- Farina, F
- Popova, M
- Zompi, S
- Audisio, E
- Ledoux, MP
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- Weinbergerova, B
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- Da Silva, MG
- Fracchiolla, N
- De Jonge, N
- Collins, G
- Marchetti, M
- Magliano, G
- Garcia-Vidal, C
- Biernat, MM
- Van Doesum, J
- Machado, M
- Demirkan, F
- Al-Khabori, M
- Zak, P
- Visek, B
- Stoma, I
- Mendez, GA
- Maertens, J
- Khanna, N
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- Jaksic, O
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