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Elevated levels of ...
Elevated levels of IgG and IgG4 to Malassezia allergens in atopic eczema patients with IgE reactivity to Malassezia
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- Johansson, C (författare)
- Karolinska Institutet
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- Linder, MT (författare)
- Karolinska Institutet
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Aalberse, RC (författare)
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- Scheynius, A (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2004-10-08
- 2004
- Engelska.
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Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1018-2438 .- 1423-0097. ; 135:2, s. 93-100
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <i>Background:</i> The opportunistic yeast <i>Malassezia</i> is considered to be one of the factors that can contribute to atopic eczema (AE). Elevated serum IgE levels, T-cell proliferation and positive skin prick test (SPT) and atopy patch test (APT) reactions to <i>Malassezia</i> are found among AE patients. <i>Methods:</i> Sera from 127 AE patients, 14 patients with seborrheic dermatitis (SD) and 33 healthy controls were investigated for IgE and IgG4 to <i>M. sympodialis </i>extract and four recombinant <i>Malassezia</i> allergens; rMala s 1, rMala s 5, rMala s 6, and rMala s 9. In addition, IgG to the recombinant allergens was analyzed. The IgG and IgG4 levels were compared to IgE levels and in vivo reactions (SPT and APT) to <i>Malassezia</i>.<i> Results:</i> AE patients with serum IgE levels >0.35 kU/l to <i>M. sympodialis</i> extract had significantly higher IgG4 levels to <i>M. sympodialis</i> extract than AE patients without detectable serum IgE to <i>M. sympodialis</i> extract, SD patients and healthy controls. Among the AE patients with and without detectable serum IgE to <i>M. sympodialis</i> extract, respectively, there were no differences in IgG4 levels between patients with positive or negative in vivo reactions to <i>M. sympodialis</i> extract. IgG4 to the rMala s allergens was almost exclusively found among patients with IgE to the same allergen. Within the four tested rMala s allergens, most IgG4 reactions were found to rMala s 6, an allergen with homology to cyclophilin. <i>Conclusions:</i> Elevated serum IgG4 to<i> M. sympodialis</i> extract accompanies elevated serum IgE to the extract. This is further confirmed by the association between IgG/IgG4 and IgE to recombinant <i>Malassezia</i> allergens.
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