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Splenic denervation...
Splenic denervation suppresses mRNA gene expression and protein production of IL-1beta and IL-6 by peritoneal macrophages in both Trypanosoma brucei brucei-infected and non-infected rats
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Liu, YJ (författare)
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- Li, ZL (författare)
- Karolinska Institutet
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Svaren-Quiding, C (författare)
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Cui, JG (författare)
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- Ozenci, V (författare)
- Karolinska Institutet
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Bakhiet, M (författare)
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(creator_code:org_t)
- 2004-02-06
- 2004
- Engelska.
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Ingår i: Neuroimmunomodulation. - : S. Karger AG. - 1021-7401 .- 1423-0216. ; 11:2, s. 113-118
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <i>Objective:</i> To test the hypothesis that the nervous system participates in modulating the immune response during experimental African trypanosomiasis caused by <i>Trypanosoma brucei brucei</i>. <i>Methods and Results:</i> Using in situ hybridization and immunochemistry, we studied the effects of splenic sympathectomy on mRNA gene expression and protein production of IL-1β and IL-6 in splenic and peritoneal macrophages (PMΦ) of Sprague-Dawley rats infected with <i>T. brucei brucei</i> and non-infected rats. The enhancements of mRNA gene expression and production of IL-1β and IL-6 by peritoneal macrophages were significantly suppressed by the splenic sympathectomy in both infected and non-infected rats. <i>Conclusions:</i> Our data indicate a probably stimulatory role of the sympathetic nervous system during the host immune response in both normal and <i>T. brucei brucei</i>-infected rats.
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