onr:"swepub:oai:prod.swepub.kib.ki.se:1929672"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02765naa a2200325 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1929672 | |
| 003 | SwePub | |
| 008 | 240701s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19296722 URI |
| 024 | 7 | a https://doi.org/10.1099/0022-1317-83-2-3692 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brinster, C4 aut |
| 245 | 1 0 | a Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles |
| 264 | 1 | b Microbiology Society,c 2002 |
| 520 | a The capacity of recombinant Semliki Forest virus particles (rSFV) expressing the hepatitis C virus non-structural protein 3 (NS3) to induce, in comparison or in combination with an NS3-expressing plasmid, specific cellular and humoral immune responses in murine models was evaluated. In vitro studies indicated that both types of vaccine expressed the expected size protein, albeit with different efficacies. The use of mice transgenic for the human HLA-A2.1 molecule indicated that the rSFV-expressed NS3 protein induces, as shown previously for an NS3 DNA vaccine, NS3-specific cytotoxic lymphocytes (CTLs) targeted at one dominant HLA-A2 epitope described in infected patients. All DNA/rSFV vaccine combinations evaluated induced specific CTLs, which were detectable for up to 31 weeks after the first injection. Overall, less than 1 log difference was observed in terms of the vigour of the bulk CTL response induced and the CTL precursor frequency between all vaccines (ranging from 1:2·6×105 to 1:1×106). Anti-NS3 antibodies could only be detected following a combined vaccine regimen in non-transgenic BALB/c mice. In conclusion, rSFV particles expressing NS3 are capable of inducing NS3-specific cellular immune responses targeted at a major HLA-A2 epitope. Such responses were comparable to those obtained with a DNA-based NS3 vaccine, whether in the context of single or combined regimens. | |
| 700 | 1 | a Chen, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Boucreux, D4 aut |
| 700 | 1 | a Paranhos-Baccala, G4 aut |
| 700 | 1 | a Liljestrom, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Lemmonier, F4 aut |
| 700 | 1 | a Inchauspe, G4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The Journal of general virologyd : Microbiology Societyg 83:Pt 2, s. 369-381q 83:Pt 2<369-381x 0022-1317x 1465-2099 |
| 856 | 4 | u https://doi.org/10.1099/0022-1317-83-2-369 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1929672 |
| 856 | 4 8 | u https://doi.org/10.1099/0022-1317-83-2-369 |
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