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Regional ventilatio...
Regional ventilation-perfusion distribution is more uniform in the prone position
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- Mure, M (författare)
- Karolinska Institutet
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Domino, KB (författare)
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- Lindahl, SGE (författare)
- Karolinska Institutet
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Hlastala, MP (författare)
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Altemeier, WA (författare)
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Glenny, RW (författare)
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(creator_code:org_t)
- American Physiological Society, 2000
- 2000
- Engelska.
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Ingår i: Journal of applied physiology (Bethesda, Md. : 1985). - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 88:3, s. 1076-1083
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The arterial blood[Formula: see text] is increased in the prone position in animals and humans because of an improvement in ventilation (V˙a) and perfusion (Q˙) matching. However, the mechanism of improvedV˙a/Q˙ is unknown. This experiment measured regionalV˙a/Q˙ heterogeneity and the correlation between V˙a andQ˙ in supine and prone positions in pigs. Eight ketamine-diazepam-anesthetized, mechanically ventilated pigs were studied in supine and prone positions in random order. RegionalV˙a and Q˙ were measured using fluorescent-labeled aerosols and radioactive-labeled microspheres, respectively. The lungs were dried at total lung capacity and cubed into 603–967 small (∼1.7-cm3) pieces. In the prone position the homogeneity of the ventilation distribution increased ( P = 0.030) and the correlation betweenV˙a and Q˙ increased (correlation coefficient = 0.72 ± 0.08 and 0.82 ± 0.06 in supine and prone positions, respectively, P = 0.03). The homogeneity of the V˙a/Q˙distribution increased in the prone position ( P = 0.028). We conclude that the improvement inV˙a/Q˙ matching in the prone position is secondary to increased homogeneity of theV˙a distribution and increased correlation of regional V˙a andQ˙.
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