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Functional p53 chim...
Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis
- Artikel/kapitelEngelska2002
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2002-01-22
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Proceedings of the National Academy of Sciences,2002
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1936898
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1936898URI
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https://doi.org/10.1073/pnas.022306499DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Functional inactivation of the tumor suppressor protein p53 by accelerated ubiquitin/proteasome-dependent proteolysis is a common event in tumor progression. Proteasomal degradation is inhibited by the Gly-Ala repeat (GAr) of the Epstein–Barr virus nuclear antigen-1, which acts as a transferable element on a variety of proteasomal substrates. We demonstrate that p53 chimeras containing GAr domains of different lengths and positions within the protein are protected from proteolysis induced by the ubiquitin ligases murine double minute 2 and E6-associated protein but are still ubiquitinated and retain the capacity to interact with the S5a ubiquitin-binding subunit of the proteasome. The GAr chimeras transactivate p53 target genes, induce cell cycle arrest and apoptosis, and exhibit improved growth inhibitory activity in tumor cells with impaired endogenous p53 activity.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Leonchiks, A
(författare)
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Issaeva, N
(författare)
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Sharipo, A
(författare)
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Selivanova, GKarolinska Institutet
(författare)
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Masucci, MGKarolinska Institutet
(författare)
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Dantuma, NPKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences99:3, s. 1532-15370027-8424
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Ingår i:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences99:3, s. 1532-15371091-6490
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