Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:1937804" > Long-term antidepre...
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000 | 02714naa a2200301 4500 | |
001 | oai:prod.swepub.kib.ki.se:1937804 | |
003 | SwePub | |
008 | 240913s2005 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19378042 URI |
024 | 7 | a https://doi.org/10.1159/0000832562 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Laska, ACu Karolinska Institutet4 aut |
245 | 1 0 | a Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: a randomised, double-blind, placebo-controlled study |
264 | c 2005-02-03 | |
264 | 1 | b S. Karger AG,c 2005 |
520 | a <i>Background and Purpose:</i> Pharmacotherapy aimed at stroke rehabilitation through direct central nervous effects may be assumed to work in a similar way for language recovery and sensory-motor recovery. Some data suggest that antidepressant drugs could be beneficial also for functional improvement. This prompted us to investigate whether regression from aphasia after acute stroke could be enhanced by antidepressive drug therapy. <i>Methods:</i> We randomised 90 acute stroke patients with aphasia to either 600 mg moclobemide or placebo daily for 6 months, within 3 weeks of the onset of stroke. Aphasia was assessed prior to treatment and at 6 months, using Reinvang’s ‘Grunntest for afasi’ and the Amsterdam-Nijmegen-Everyday-Language-Test (ANELT). <i>Result:</i> The degree of aphasia decreased significantly at 6 months, with no difference between the moclobemide- and the placebo-treated groups. Multivariate regression analysis including treatment group, activities of daily living, aetiology of stroke, ANELT, and Reinvang’s coefficient at baseline, and neurological deficit confirmed these results. In all, 13 in the moclobemide and 10 in the placebo group stopped taking the study medication. No further change was found in the 56 aphasic patients followed up for another 6 months with no medication. <i>Conclusions:</i> Compared to placebo, treatment with moclobemide for 6 months did not enhance the regression of aphasia following an acute stroke. | |
700 | 1 | a von Arbin, Mu Karolinska Institutet4 aut |
700 | 1 | a Kahan, Tu Karolinska Institutet4 aut |
700 | 1 | a Hellblom, A4 aut |
700 | 1 | a Murray, Vu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Cerebrovascular diseases (Basel, Switzerland)d : S. Karger AGg 19:2, s. 125-132q 19:2<125-132x 1015-9770x 1421-9786 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1937804 |
856 | 4 8 | u https://doi.org/10.1159/000083256 |
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