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Isomer-specific ant...
Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression
- Artikel/kapitelEngelska2001
Förlag, utgivningsår, omfång ...
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American Diabetes Association,2001
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1938242
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1938242URI
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https://doi.org/10.2337/diabetes.50.5.1149DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator–activated receptor (PPAR)-γ response elements in vitro. Here, our aim was to elucidate the effect(s) of specific CLA isomers on whole-body glucose tolerance, insulin action in skeletal muscle, and expression of genes important in glucose and lipid metabolism. ZDF rats were fed either a control diet (CON), one of two CLA supplemented diets (1.5% CLA) containing differing isoforms of CLA (47% c9,t11; 47.9% c10,t12, 50:50; or 91% c9,t11, c9,t11 isomers), or were pair-fed CON diet to match the intake of 50:50. The 50:50 diet reduced adiposity and improved glucose tolerance compared with all other ZDF treatments. Insulin-stimulated glucose transport and glycogen synthase activity in skeletal muscle were improved with 50:50 compared with all other treatments. Neither phosphatidlyinositol 3-kinase activity nor Akt activity in muscle was affected by treatment. Uncoupling protein 2 in muscle and adipose tissue was upregulated by c9,t11 and 50:50 compared with ZDF controls. PPAR-γ mRNA was downregulated in liver of c9,t11 and pair-fed ZDF rats. Thus, the improved glucose tolerance in 50:50 rats is attributable to, at least in part, improved insulin action in muscle, and CLA effects cannot be explained simply by reduced food intake.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Portocarrero, CP
(författare)
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Song, XM
(författare)
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Cui, L
(författare)
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Yu, M
(författare)
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Combatsiaris, T
(författare)
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Galuska, DKarolinska Institutet
(författare)
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Bauman, DE
(författare)
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Barbano, DM
(författare)
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Charron, MJ
(författare)
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Zierath, JRKarolinska Institutet
(författare)
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Houseknecht, KL
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes: American Diabetes Association50:5, s. 1149-11570012-17971939-327X
Internetlänk
Hitta via bibliotek
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Diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Ryder, JW
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Portocarrero, CP
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Song, XM
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Cui, L
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Yu, M
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Combatsiaris, T
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visa fler...
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Galuska, D
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Bauman, DE
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Barbano, DM
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Charron, MJ
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Zierath, JR
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Houseknecht, KL
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visa färre...
- Artiklar i publikationen
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Diabetes
- Av lärosätet
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Karolinska Institutet