Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:1938242" > Isomer-specific ant...
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000 | 03019naa a2200385 4500 | |
001 | oai:prod.swepub.kib.ki.se:1938242 | |
003 | SwePub | |
008 | 240913s2001 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19382422 URI |
024 | 7 | a https://doi.org/10.2337/diabetes.50.5.11492 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ryder, JW4 aut |
245 | 1 0 | a Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression |
264 | 1 | b American Diabetes Association,c 2001 |
520 | a Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator–activated receptor (PPAR)-γ response elements in vitro. Here, our aim was to elucidate the effect(s) of specific CLA isomers on whole-body glucose tolerance, insulin action in skeletal muscle, and expression of genes important in glucose and lipid metabolism. ZDF rats were fed either a control diet (CON), one of two CLA supplemented diets (1.5% CLA) containing differing isoforms of CLA (47% c9,t11; 47.9% c10,t12, 50:50; or 91% c9,t11, c9,t11 isomers), or were pair-fed CON diet to match the intake of 50:50. The 50:50 diet reduced adiposity and improved glucose tolerance compared with all other ZDF treatments. Insulin-stimulated glucose transport and glycogen synthase activity in skeletal muscle were improved with 50:50 compared with all other treatments. Neither phosphatidlyinositol 3-kinase activity nor Akt activity in muscle was affected by treatment. Uncoupling protein 2 in muscle and adipose tissue was upregulated by c9,t11 and 50:50 compared with ZDF controls. PPAR-γ mRNA was downregulated in liver of c9,t11 and pair-fed ZDF rats. Thus, the improved glucose tolerance in 50:50 rats is attributable to, at least in part, improved insulin action in muscle, and CLA effects cannot be explained simply by reduced food intake. | |
700 | 1 | a Portocarrero, CP4 aut |
700 | 1 | a Song, XM4 aut |
700 | 1 | a Cui, L4 aut |
700 | 1 | a Yu, M4 aut |
700 | 1 | a Combatsiaris, T4 aut |
700 | 1 | a Galuska, Du Karolinska Institutet4 aut |
700 | 1 | a Bauman, DE4 aut |
700 | 1 | a Barbano, DM4 aut |
700 | 1 | a Charron, MJ4 aut |
700 | 1 | a Zierath, JRu Karolinska Institutet4 aut |
700 | 1 | a Houseknecht, KL4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Diabetesd : American Diabetes Associationg 50:5, s. 1149-1157q 50:5<1149-1157x 0012-1797x 1939-327X |
856 | 4 | u http://diabetes.diabetesjournals.org/content/50/5/1149.full.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938242 |
856 | 4 8 | u https://doi.org/10.2337/diabetes.50.5.1149 |
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