Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:1939127" >
Growth hormone trea...
Growth hormone treatment downregulates serum leptin levels in children independent of changes in body mass index
-
Elimam, A (författare)
-
Lindgren, AC (författare)
-
- Norgren, S (författare)
- Karolinska Institutet
-
visa fler...
-
Kamel, A (författare)
-
- Skwirut, C (författare)
- Karolinska Institutet
-
- Bang, P (författare)
- Karolinska Institutet
-
- Marcus, C (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2000-02-03
- 1999
- Engelska.
-
Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 52:2, s. 66-72
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The changes in serum leptin levels during growth hormone (GH) treatment were studied in 27 children, 17 with GH deficiency (GHD), 10 with idiopathic short stature (ISS), and 9 with Prader-Willi syndrome (PWS). Within 1 month of GH treatment, serum leptin levels decreased by 40% in the GHD children (p < 0.01). There was no significant change in serum leptin level in the children with ISS. In children with PWS, the mean serum leptin level decreased by almost 60% after 3 months of treatment (p < 0.001). Thereafter, no further decline was observed in any of the 3 groups. Changes in body composition became evident first after the 3 months of treatment. In the GHD children, the BMI was unchanged while the mean body fat percentage was 2.7% lower after 1 year of GH treatment (p < 0.05). In the ISS children, neither BMI nor body fat percentage were significantly changed during treatment. The PWS children exhibited a significant decrease in BMI after 6 months of GH treatment without any further change during the remaining period of treatment. In this group, the mean body fat percentage decreased from 42 ± 2.4 to 28 ± 2.2% after treatment (p < 0.001). The finding that the fall in leptin occurs before changes in body composition become detectable suggests a direct effect of GH on leptin production, metabolism, or clearance.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas