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Inactivation of liv...
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Andersson, S
(författare)
Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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2005-02-28
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Proceedings of the National Academy of Sciences,2005
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1951198
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1951198URI
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https://doi.org/10.1073/pnas.0500634102DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Male mice with inactivated liver X receptor (LXR) β suffer from adult-onset motor neuron degeneration. By 7 months of age, motor coordination is impaired, and this condition is associated with lipid accumulation and loss of motor neurons in the spinal cord, together with axonal atrophy and astrogliosis. Several of these features are reminiscent of the neuropathological signs of chronic motor neuron disease such as amyotrophic lateral sclerosis. Because the LXRs are important for cholesterol and lipid metabolism, we speculate that absence of LXRβ leads to pathological accumulation of sterols and lipids that may themselves be neurotoxic or may modulate intracellular pathways and thereby predispose motor neurons to degeneration.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gustafsson, NKarolinska Institutet
(författare)
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Warner, M
(författare)
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Gustafsson, JAKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences102:10, s. 3857-38620027-8424
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Ingår i:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences102:10, s. 3857-38621091-6490
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