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Genetic contributio...
Genetic contributions to generalized arousal of brain and behavior
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Garey, J (författare)
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Goodwillie, A (författare)
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Frohlich, J (författare)
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Morgan, M (författare)
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- Gustafsson, JA (författare)
- Karolinska Institutet
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Smithies, O (författare)
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Korach, KS (författare)
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Ogawa, S (författare)
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Pfaff, DW (författare)
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(creator_code:org_t)
- 2003-08-20
- 2003
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 100:19, s. 11019-11022
- Relaterad länk:
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https://www.pnas.org...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.
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- art (ämneskategori)
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