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Estrogen inhibits t...
Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice
- Artikel/kapitelEngelska1999
Förlag, utgivningsår, omfång ...
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1999-12-21
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Proceedings of the National Academy of Sciences,1999
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:1956310
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1956310URI
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https://doi.org/10.1073/pnas.96.26.15133DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two estrogen receptors have been identified, ERα and ERβ. We demonstrated previously that estrogen inhibits the response to vascular injury in both wild-type and ERα-deficient mice, and that ERβ is expressed in the blood vessels of each, suggesting a role for ERβ in the vascular protective effects of estrogen. In the present study, we examined the effect of estrogen administration on mouse carotid arterial injury in ERβ-deficient mice. Surprisingly, in ovariectomized female wild-type and ERβ knockout mice, 17β-estradiol markedly and equally inhibited the increase in vascular medial area and the proliferation of vascular smooth muscle cells after vascular injury. These data demonstrate that ERβ is not required for estrogen-mediated inhibition of the response to vascular injury, and suggest that either of the two known estrogen receptors is sufficient to protect against vascular injury, or that another unidentified estrogen receptor mediates the vascular protective effects of estrogen.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hodgin, JB
(författare)
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Kwoun, M
(författare)
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Krege, JH
(författare)
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Aronovitz, M
(författare)
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Mackey, W
(författare)
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Gustafsson, JAKarolinska Institutet
(författare)
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Korach, KS
(författare)
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Smithies, O
(författare)
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Mendelsohn, ME
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences96:26, s. 15133-151360027-8424
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Ingår i:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences96:26, s. 15133-151361091-6490
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Till lärosätets databas
- Av författaren/redakt...
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Karas, RH
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Hodgin, JB
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Kwoun, M
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Krege, JH
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Aronovitz, M
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Mackey, W
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visa fler...
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Gustafsson, JA
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Korach, KS
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Smithies, O
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Mendelsohn, ME
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visa färre...
- Artiklar i publikationen
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Proceedings of t ...
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Proceedings of t ...
- Av lärosätet
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Karolinska Institutet