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The role of dendrit...
The role of dendritic cells in the pathogenesis of HIV-1 infection
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- Lore, Karin (författare)
- Karolinska Institutet,Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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- Larsson, Marie, 1966- (författare)
- The Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, USA
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(creator_code:org_t)
- Wiley, 2003
- 2003
- Engelska.
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Ingår i: Journal of Pathology, Microbiology and Immunology - the APMIS journal. - : Wiley. - 0903-4641 .- 1600-0463. ; 111:7-8, s. 776-788
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Abstract
Ämnesord
Stäng
- Dendritic cells are professional antigen-presenting cells required for generation of adaptive immunity. These cells are one of the initial target cells for HIV-1 infection or capture of virions at site of transmission in the mucosa. DCs carrying HIV-1 will migrate to the lymphoid tissue where they can contribute to the dissemination of the virus to adjacent CD4+ T cells. In addition, HIV-1–exposed DCs may have impaired antigen-presenting capacity resulting in inadequate expansion of HIV-1–specific T cell responses. Here, we review the infection of different subtypes of DCs by HIV-1 and the relevance of these cells in the transmission and establishment of HIV-1 disease. In addition, we discuss the mechanisms through which HIV-1–DC interactions could be exploited to optimise the generation and maintenance of HIV-1–specific T cell immunity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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