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Animal model for th...
Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors
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UBERLA, K (författare)
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STAHLHENNIG, C (författare)
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BOTTIGER, D (författare)
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MATZRENSING, K (författare)
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KAUP, FJ (författare)
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LI, J (författare)
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HASELTINE, WA (författare)
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FLECKENSTEIN, B (författare)
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HUNSMANN, G (författare)
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OBERG, B (författare)
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SODROSKI, J (författare)
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- 1995-08-29
- 1995
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 92:18, s. 8210-8214
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http://www.pnas.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) is the major target for antiretroviral therapy of the acquired immunodeficiency syndrome (AIDS). While some inhibitors exhibit activity against most retroviral RTs, others are specific for the HIV-1 enzyme. To develop an animal model for the therapy of the HIV-1 infection with RT inhibitors, the RT of the simian immunodeficiency virus (SIV) was replaced by the RT of HIV-1. Macaques infected with this SIV/HIV-1 hybrid virus developed AIDS-like symptoms and pathology. The HIV-1-specific RT inhibitor LY300046.HCl, but not zidovudine [3'-azido-3'-deoxythymidine (AZT)] delayed the appearance of plasma antigenemia in macaques infected with a high dose of the chimeric virus. Infection of macaques with the chimeric virus seems to be a valuable model to study the in vivo efficacy of new RT inhibitors, the emergence and reversal of drug resistance, the therapy of infections with drug-resistant viruses, and the efficacy of combination therapy.
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UBERLA, K
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STAHLHENNIG, C
-
BOTTIGER, D
-
MATZRENSING, K
-
KAUP, FJ
-
LI, J
-
visa fler...
-
HASELTINE, WA
-
FLECKENSTEIN, B
-
HUNSMANN, G
-
OBERG, B
-
SODROSKI, J
-
visa färre...
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Karolinska Institutet