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Effect of long-term...
Effect of long-term oxygen therapy on cognitive and neurological dysfunction in chronic obstructive pulmonary disease
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Hjalmarsen, A (författare)
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Waterloo, K (författare)
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Dahl, A (författare)
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Jorde, R (författare)
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- Viitanen, M (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 1999-07-06
- 1999
- Engelska.
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Ingår i: European neurology. - : S. Karger AG. - 0014-3022 .- 1421-9913. ; 42:1, s. 27-35
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The aim of this study was to assess effect of long-term oxygen therapy (LTOT) on the function of central and autonomic nervous system in patients with hypoxaemic chronic obstructive pulmonary disease (COPD). A battery of neuropsychological tests was used together with the Short Test of Mental Status in addition to transcranial Doppler ultrasonography, and five cardiovascular tests as well as a questionnaire on autonomic function. Ten COPD patients, 4 males and 6 females, with a mean age of 65.9 ± 7.3 (SD) years, were studied at the beginning and after 3 months of LTOT. At start PaO<sub>2</sub> was 6.7 ± 1.1 kPa without oxygen and 9.9 ± 1.5 kPa after 3 months with oxygen. Our results demonstrate that neuropsychological function, cerebral blood flow velocity and autonomic function were positively influenced after 3 months of LTOT although the changes did not reach statistical significance. The COPD patients were cognitively impaired as compared to age-matched healthy controls. Our findings were consistent with the previous notion of improvement of hypoxic cognitive dysfunction by LTOT.
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